Table 1 Clinical characteristics of 11 patients with thrombosis combined with bleeding out of the 1137 patients at high risk for thrombosis.

From: Clinical analysis of bleeding and thrombotic events in haematological-oncology patients with severe thrombocytopenia and a high risk of thrombosis

Variables

Thrombosis with bleeding

Variables

Thrombosis with bleeding

Physical characteristics of patients

Laboratory tests

Gender, n (%)

 

Liver and kidney function at admission

Male

7 (63.64)

Albumin (g/L)

35.78 ± 4.90

Female

4 (36.36)

Creatinine (µmol/L)

70.50 (58.90-85.55)

Age (years)

52.09 ± 20.04

GFR(mL/min)

69.54 ± 32.67

Weight (kg)

62.27 ± 14.19

CCr (mL/min)

87.80 (40.30-119.80)

Height (cm)

162.82 ± 9.06

Minimum platelet count (×109 /L)

25(5–58)

BMI, kg/m2

22.67 (19.63–24.22)

Diagnostic and treatment status

Patient health history

Bedridden > 72 h, n (%)

5 (45.45)

Smoking history, n (%)

3 (27.27)

Intravenous catheter placement, n (%)

8 (72.73)

History of alcohol consumption, n (%)

1 (9.09)

Types of intravenous catheter, n (%)

History of diabetes, n (%)

1 (9.09)

PICC

6 (75.00)

History of hypertension, n (%)

0 (0.00)

CVC

2 (25.00)

History of coronary heart disease, n (%)

0 (0.00)

Number of intravenous catheter lumens, n (%)

History of hyperlipidaemia, n (%)

0 (0.00)

One

5 (62.50)

History of thrombosis, n (%)

3 (27.27)

Two

3 (37.50)

Characteristics of the disease

Length of time the intravenous catheter (day)

105.88 ± 91.00

Type of haematological malignancies, n (%)

Erythropoietin, n (%)

1 (9.09)

Leukaemia

6 (54.55)

Parenteral nutrition, n (%)

7 (63.64)

Lymphomas

3 (27.27)

Steroids, n (%)

7 (63.64)

Plasma cell tumour

2 (18.18)

Immunomodulators, n (%)

1 (9.09)

Cell source of malignancies, n (%)

Sedatives, n (%)

2 (18.18)

Myeloid

6 (54.55)

Chemotherapy, n (%)

8 (72.73)

B-lineage

5 (45.45)

Auto-HSCT, n (%)

2 (18.18)

Lower limb oedema, n (%)

1 (9.09)

Patient outcomes

 

Septicaemia, n (%)

4 (36.36)

Survival outcome, n (%)

Mediastinal involvement of lymph nodes, n (%)

2 (18.18)

Survive

10 (90.91)

Extranodal diseases, n (%)

0 (0.00)

Dead

1 (9.09)

Lung infection, n (%)

8 (72.73)

Bleeding-thrombosis sequence, n (%)

CCI score

4(3–5)

Thrombus priority

5 (45.45)

Caprini score

6(6–7)

Bleeding priority

4 (36.36)

ISTH DIC score

5.33 ± 1.58

Bleeding-thrombosis at the same time

2 (18.18)

  1. BMI, body mass index; CCI, Charlson Comorbidity Index; PICC, peripherally inserted central catheter; CVC, central venous catheter; GFR, glomerular filtration rate; CCr, endogenous creatinine clearance rate; Auto-HSCT, autologous haematopoietic stem cell transplantation.