Table 2 Incidence and severity of histopathological changes of lung tissues in PHMG-P-treated adult mice.
Adult male | Adult female | ||||||
|---|---|---|---|---|---|---|---|
Control | Low | High | Control | Low | High | ||
Number of examined | 4 | 4 | 4 | 4 | 4 | 4 | |
Number of unremarkable | 4 | 0 | 0 | 4 | 0 | 0 | |
Alveolar bronchiolization | Count | 0 | 2 | 4 | 0 | 4 | 4 |
Average severityb | 0.00a | 2.00 | 1.00 | 0.00 | 1.25 | 2.00 | |
Scoringc | 0.00 | 1.00 | 1.00 | 0.00 | 1.25 | 2.00 | |
Foamy/alveolar macrophage | Count | 0 | 4 | 4 | 0 | 4 | 4 |
Average severity | 0.00 | 1.50 | 2.25 | 0.00 | 1.25 | 2.25 | |
Scoring | 0.00 | 1.50 | 2.25 | 0.00 | 1.25 | 2.25 | |
Granulomatous inflammation/fibrosis | Count | 0 | 4 | 4 | 0 | 4 | 4 |
Average severity | 0.00 | 1.50 | 2.50 | 0.00 | 1.25 | 2.50 | |
Scoring | 0.00 | 1.50 | 2.50 | 0.00 | 1.25 | 2.50 | |
Inflammatory cell infiltration | Count | 0 | 4 | 4 | 0 | 4 | 4 |
Average severity | 0.00 | 2.00 | 1.00 | 0.00 | 1.50 | 2.25 | |
Scoring | 0.00 | 2.00 | 1.00 | 0.00 | 1.50 | 2.25 | |
Degeneration of bronchiolar epitheliums | Count | 0 | 3 | 3 | 0 | 4 | 4 |
Average severity | 0.00 | 1.33 | 2.67 | 0.00 | 1.25 | 2.25 | |
Scoring | 0.00 | 1.00 | 2.00 | 0.00 | 1.25 | 2.25 | |
