Fig. 5
Gene ontology (GO) enrichment analysis of modulated proteins in 3D cultures of Hs578t cells co-cultured with adipocytes. (A-B) An advanced bubble plot showed the top 10 GO enrichment significance elements of the upregulated (A) and (B) downregulated proteins ordered by adjusted P-value. Cellular component (CC), molecular function (MF), and biological process (BP). The x-axis label represented the proportion of genes, and the y-axis label represented the GO terms. (C-D) The chord chart showed the distribution of proteins in different GO-enriched functions. The symbols of the genes coding for the proteins were presented on the left side of the graph, with their fold-change values denoted by color scale. Colored connecting lines indicate the involvement of the genes in the GO terms.
