Fig. 5 | Scientific Reports

Fig. 5

From: Suppression of JNK pathway protects neurons from oxidative injury via attenuating parthanatos in glutamate-treated HT22 neurons

Fig. 5

JNK signalling inhibition altered DCFH-DA fluorescence at 12 h in glutamate-treated HT22 neurons. (a) Fluorescence immunohistochemistry of DCFH-DA staining, with significantly higher green signal in glutamate-treated HT22 neurons; SP600125 decreased green fluorescence intensity. (b) pre-treatment with the JNK inhibitor SP600125 attenuated hydrogen peroxide overproduction in glutamate-treated HT22 neurons, as determined using flow cytometry. Data are expressed as mean ± standard deviation (SD; *p < 0.05, **p < 0.01).

Back to article page