Fig. 6 | Scientific Reports

Fig. 6

From: Suppression of JNK pathway protects neurons from oxidative injury via attenuating parthanatos in glutamate-treated HT22 neurons

Fig. 6

JNK signalling inhibition altered DHE fluorescence at 12 h in glutamate-treated HT22 neurons. (a) Fluorescence immunohistochemistry of DHE, red fluorescence was significantly higher in glutamate-treated HT22 neurons, and SP600125 decreased red fluorescence. (b) pre-treatment with the JNK inhibitor SP600125 attenuated superoxide anion overproduction in glutamate-treated HT22 neurons, as determined using flow cytometry. Data are expressed as mean ± standard deviation (SD; *p < 0.05, **p < 0.01).

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