Fig. 1 | Scientific Reports

Fig. 1

From: Elucidating the role of CYFIP2 in conferring cisplatin resistance in esophageal squamous cell carcinoma

Fig. 1

Screening for CDDP-associated genes in ESCC cells. (A) Schematic illustration of sgRNA library screening procedure to identify genes responsible for CDDP-resistance in TE-1 cells. (B) The raw data obtained from genome sequencing (gRNA sequencing) go through the bioinformatics analysis steps. (C) Volcano plot based on MAGeCK algorithms showing negatively (blue) and positively (red) selected genes in library screens, and the specific location of gRNA was determined by the fold change and p-value. (D) GSEA (KEGG gene sets) was performed based on negative screening and positive screening genes, with blue and red marked, respectively. (E) GSEA for autophagy in negative screening.

Back to article page