Figure 4

Boxplot of average retinal sensitivity (RS) depending on the baseline local retinal pathology and line plot showing height of pathologic lesion. Average RS is presented at the bottom of each graph. (mean RS) (A) Average baseline RS. Baseline RS was worst when IRF is present. And RS at SHRM follows. (B) nl: No abnormality is found (C) SRF: Subretinal fluid (D) IRF: Intraretinal fluid (IRF) (E) SPED: Serous pigment epithelial detachment (F) FPED: Fibrovascular pigment epithelial detachment (G) SHRM: Subretinal hyperreflective material (H) NVC: Neovascular complex. Multiple retinal pathology can be present at the same loci simultaneously. Asterisks (*) indicates when P value of Wilcoxon signed rank test is below 0.05, comparing average RS of each visit to that of baseline visit (visit 1). RS over the any kind of retinal pathology improved from the one month after the intravitreal aflibercept injection, except for the IRF and SPED. While RS on the SPED improved at last visit, that of IRF showed improvement only at visit 2. The height of lesion decreased rapidly from one month after the first treatment and almost resolved at last visit in all pathology.