Fig. 2

Time-series gut (fecal) microbiota alteration of healthy control (abbreviated Wt) and lupus mice, including pristane (Pt) amd FcGRIIb-/- (Ko), as indicated by alpha diversity indices at genus levels of (A) number of operational taxonomic units (OTUs), (B) Chao richness and (C) Shannon diversity; (D-F) percent relative abundance of bacterial phylum OTUs (p_ abbreviates phylum, “Other phyla (< 0.05)” represents phyla that each contain < 0.05% frequency, and F/B ratio represents Firmicutes-to-Bacteroidetes ratio); (G) percent relative abundance of bacterial genus OTUs (g_ abbreviates genus, c_ class, o_ order, f_ family, and “Other genera (< 1%)” represents genera that each contain < 1%); and (H) relative percent abundance of specific bacterial species. Colored dot represents relative abundance of each sample. In (A-C) colored line (pale blue, pink, and red, pink) represents the average of samples in each group. “*” represents significant difference between healthy and lupus-prone mice (pristane or knockout) (p ≤ 0.05) calculated by ANOVA. In (G), the OTUs where Mothur could not identify the genus names were denoted by small letters to the deepest taxonomic names that could be identified (e.g., o_ abbreviates order). Data were from 3–5 mice per group.