Fig. 4

Representing preclinical (4 month) and established SLE (11 month) time point analyses of different intestinal section (duodenum, jejunum, ileum, cecum, or colon) microbiota compositions in healthy control (abbreviated Wt) and lupus mice pristane (Pt) amd FcGRIIb-/- (Ko), as indicated by alpha diversity indices at genus levels of (A) number of OTUs, (B) Chao richness and (C) Shannon diversity; (D) percent relative abundance of bacterial phylum OTUs (p_ abbreviates phylum, and “Other phyla (≤ 0.01)” represents phyla that each contain < 0.01% frequency) (feces samples were included); and (E) percent relative abundance of bacterial genus OTUs (g_ abbreviates genus, c_ class, o_ order, f_ family, and “Other genera (≤ 1)” represents genera that each contain ≤ 1%) (feces samples were included). In (A-C) colored line (pale blue, pink, and red, pink) represents the average of samples in each group. “*” represents significant difference between healthy and lupus-prone mice (pristane or knockout) (p ≤ 0.05) calculated by ANOVA. In (E), the OTUs where Mothur could not identify the genus names were denoted by small letters to the deepest taxonomic names that could be identified (e.g., o_ abbreviates order). Data were from 3–5 mice per group.