Fig. 2 | Scientific Reports

Fig. 2

From: Immune cells mediate the causal relationship between uveitis and colorectal cancer via Mendelian randomization analysis

Fig. 2The alternative text for this image may have been generated using AI.

Mendelian randomization research process. (A) The total effect between uveitis and colorectal cancer. c represents the overall effect of exposure to colorectal cancer on the outcome of uveitis, while d represents the overall effect of exposure to uveitis on the outcome of colorectal cancer. (B) The overall effect can be divided into two parts .(i) indirect effects (a × b) generated by two-step Mendelian randomization(a represents the effect of uveitis exposure on the outcome of immune cells, b represents the effect of immune cell exposure on the outcome of colorectal cancer). (ii) direct effect (c′=c–a×b). The proportion of the mediated effect is the ratio of the indirect effect to the total effect.

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