Figure 2
The NADPH-d positive alterations in the white matter and DREZ of the sacral spinal cord. The location and morphology of the megaloneurites and ANBs in the white matter and LCP of the sacral spinal cord of aged monkeys (A). NADPH-d positive activity in the sacral spinal cord of young monkeys (B). In the longitudinal section, NADPH-d staining fibers in the white matter of the lateral fasciculus of the aged monkeys (C) and young monkeys (D). The distribution of NADPH-d activities in the DREZ of the sacral spinal cord of aged monkeys (E) and young monkeys (F). Longitudinal sections of aged monkeys (G) at the sacral segment showed aberrant NADPH-d positive megaloneurites in the DREZ, transitionally continuous with LT. The illustration represents the magnification of the corresponding rectangular frame. Asterisks indicate vascular structures in C and D. Open arrowheads: NADPH-d positive neurons, black arrowheads: ANBs, open arrows: normal NADPH-d positive neurites, white arrowheads: megaloneurites. Scale bar = 50 μm.
