Table 1 Correlations between LNM and clinicopathological characteristics of patients with concurrent PTC and HT.
Category | Total, n (%) | Metastasis, n (%) | Non-metastasis, n (%) | P |
|---|---|---|---|---|
No. of patients | 271 | 122 (45) | 149 (55) | |
CLNM | 93 (76.2) | |||
LLNM | 29 (23.8) | |||
1–5 LNM | 91 (74.6) | |||
> 5 LNM | 31 (25.4) | |||
Age (mean ± SD, years) | 41.72 ± 11.02 | 38.22 ± 10.44 | 44.58 ± 10.68 | < 0.001* |
<55 | 238 (87.8) | 113 (92.6) | 125 (83.9) | 0.029* |
≥ 55 | 33 (12.2) | 9 (7.4) | 24 (16.1) | |
Gender | ||||
Male | 38 (14) | 17 (13.9) | 21 (14.1) | 0.970 |
Female | 233 (86) | 105 (86.1) | 128 (85.9) | |
BRAF V600E mutation | ||||
Yes | 192 (78.7) | 90 (79.6) | 102 (77.9) | 0.734 |
No | 52 (21.3) | 23 (20.4) | 29 (22.1) | |
TMD (mean ± SD, cm) | 1.21 ± 0.78 | 1.47 ± 0.93 | 0.99 ± 0.56 | < 0.001* |
≤ 1 cm | 157 (57.9) | 52 (42.6) | 105 (70.5) | < 0.001* |
>1 cm | 114 (42,1) | 70 (57.4) | 44 (29.5) | |
Sum of tumor diameters (mean ± SD, cm) | 1.46 ± 0.95 | 1.71 ± 1.03 | 1.25 ± 0.82 | < 0.001* |
Multifocality | ||||
Yes | 89 (32.8) | 42 (34.4) | 47 (31.5) | 0.615 |
No | 182 (67.2) | 80 (65.6) | 102 (68.5) | |
Tumor location (L/R/I/B) | ||||
Left | 107 (39.5) | 48 (39.3) | 59 (39.6) | 0.512 |
Right | 105 (38.7) | 47 (38.5) | 58 (38.9) | |
Isthmus | 6 (2.2) | 1 (0.8) | 5 (3.4) | |
Bilateral | 53 (19.6) | 26 (21.3) | 27 (18.1) | |
Calcification | ||||
Yes | 200 (73.8) | 105 (86.1) | 95 (63.8) | < 0.001* |
No | 71 (26.2) | 17 (13.9) | 54 (36.2) | |
Capsular invasion | ||||
Yes | 51 (18.8) | 24 (19.7) | 27 (18.1) | 0.745 |
No | 220 (81.2) | 98 (80.3) | 122 (81.9) | |
Extrathyroidal extension | ||||
Yes | 6 (2.2) | 4 (3.3) | 2 (1.3) | 0.414 |
No | 265 (97.8) | 118 (96.7) | 147 (98.7) | |
Aspect ratio | ||||
≤ 1 | 97 (35.8) | 36 (29.5) | 61 (40.9) | 0.051 |
> 1 | 174 (64.2) | 86 (70.5) | 88 (59.1) | |
Vascular invasion | ||||
Yes | 10 (3.7) | 6 (4.9) | 4 (2.7) | 0.353 |
No | 261 (96.3) | 116 (95.1) | 145 (97.3) | |
TG (mean ± SD, ng/ml) | 18.58 ± 55.16 | 14.69 ± 50.10 | 21.75 ± 58.95 | |
TgAb (mean ± SD, IU/mL) | 593.33 ± 912.61 | 690.00 ± 1031.81 | 515.21 ± 798.64 | 0.122 |
Normal | 84(31) | 30(24.6) | 54(36.2) | 0.039* |
High | 187(69) | 92(75.4) | 95(63.8) | |
TPOAb (mean ± SD, IU/mL) | 181.61 ± 192.80 | 184.97 ± 203.70 | 178.91 ± 184.27 | 0.800 |
Normal | 95(35.1) | 44(36.1) | 51(34.2) | 0.752 |
High | 176(64.9) | 78(63.9) | 98(65.8) | |
FT3 (mean ± SD, pmol/L) | 4.89 ± 0.79 | 5.02 ± 0.74 | 4.78 ± 0.81 | 0.010* |
FT4 (mean ± SD, pmol/L) | 16.43 ± 3.07 | 16.67 ± 2.99 | 16.23 ± 3.14 | 0.246 |
TSH (mean ± SD, mIU/L) | 2.85 ± 1.96 | 2.64 ± 1.92 | 3.03 ± 1.99 | 0.102 |
PTH (mean ± SD, pg/ml) | 41.86 ± 36.95 | 37.88 ± 16.35 | 45.06 ± 47.30 | 0.132 |
Leukocyte count (mean ± SD, 10^9/L) | 5.78 ± 1.40 | 5.83 ± 1.39 | 5.73 ± 1.42 | 0.578 |
Erythrocyte count (mean ± SD, 10^12/L) | 4.87 ± 8.02 | 4.41 ± 0.51 | 5.26 ± 10.83 | 0.389 |
Hemoglobin (mean ± SD, g/L) | 129.59 ± 15.79 | 129.61 ± 14.86 | 129.58 ± 16.57 | 0.990 |
Platelet count (mean ± SD, 10^9/L) | 215.27 ± 58.83 | 214.19 ± 56.47 | 216.17 ± 60.89 | 0.783 |
Vitamin D3 (mean ± SD, nmol/L) | 20.48 ± 7.86 | 20.57 ± 8.10 | 20.39 ± 7.67 | 0.881 |
Serum Ca2+(mean ± SD, mmol/L) | 2.32 ± 0.15 | 2.32 ± 0.12 | 2.32 ± 0.17 | 0.954 |
