Table 2 Correlations analysis of the quantity or regions of LNM in patients diagnosed with lymph node metastasis.

From: Predicting lymph node metastasis in papillary thyroid carcinoma with Hashimoto’s thyroiditis using regression and network analysis

Category

Total, n (%)

Quantity

Region

1–5 LNM, n (%)

>5 LNMs, n (%)

P

CLNM, n (%)

LLNM, n (%)

P

No. of patients

122

91 (74.6)

31 (25.4)

 

93 (76.2)

29 (23.8)

 

Age (mean ± SD, years)

41.72 ± 11.02

39.12 ± 10.39

35.58 ± 10.30

0.103

38.26 ± 10.20

38.10 ± 11.36

0.945

<55

113 (92.6)

85 (93.4)

28(90.3)

0.691

88 (94.6)

25 (86.2)

0.214

≥ 55

9 (7.4)

6.6

3 (9.7)

 

5 (5.4)

4 (13.8)

 

Gender

       

male

17 (13.9)

15 (16.5)

2 (6.5)

0.233

13 (14)

4 (13.8)

1.000

Female

105 (86.1)

76 (83.5)

29 (93.5)

 

80 (86)

25 (86.2)

 

BRAF V600E mutation

       

Yes

90 (79.6)

70 (83.3)

20 (69)

0.098

68 (79.1)

22 (81.5)

0.786

No

23 (20.4)

14 (16.7)

9 (31)

 

18 (20.9)

5 (18.5)

 

TMD (mean ± SD, cm)

1.21 ± 0.78

1.32 ± 0.82

1.88 ± 1.10

0.003*

1.33 ± 0.74

1.90 ± 1.29

0.031*

≤ 1 cm

52 (42.6)

44 (48.4)

8 (25.8)

0.028*

42 (45.2)

10 (34.5)

0.310

>1 cm

70 (57.4)

47 (51.6)

23 (74.2)

 

51 (54.8)

19 (65.5)

 

Sum of tumor diameters (mean ± SD, cm)

1.46 ± 0.95

1.58 ± 0.97

2.11 ± 1.13

0.013*

1.57 ± 0.91

2.17 ± 1.28

0.026*

Multifocality

       

Yes

42 (34.4)

32 (35.2)

10 (32.3)

0.769

32 (34.4)

10 (34.5)

0.994

No

80 (65.6)

59 (64.8)

21 (67.7)

 

61 (65.6)

19 (65.5)

 

Tumor location (L/R/I/B)

       

Left

48 (39.3)

34 (37.4)

14 (45.2)

0.832

36 (38.7)

12 (41.4)

0.948

Right

47 (38.5)

36 (39.6)

11 (35.5)

 

36 (38.7)

11 (37.9)

 

Isthmus

1 (0.8)

1 (1.1)

0(0)

 

1 (1,1)

0 (0)

 

Bilateral

26 (21.3)

20 (22)

6 (19.4)

 

20 (21.5)

6 (20.7)

 

Calcification

       

Yes

105 (86.1)

78 (85.7)

27 (87.1)

1.000

80 (86)

25 (86.2)

1.000

No

17 (13.9)

13 (14.3)

4 (12.9)

 

13 (14)

4 (13.8)

 

Capsular invasion

       

Yes

24 (19.7)

14 (15.4)

10 (32.3)

0.041*

18 (19.4)

6 (20.7)

0.875

No

98 (80.3)

77 (84.6)

21 (67.7)

 

75 (80.6)

23 (79.3)

 

Extrathyroidal extension

       

Yes

4 (3.3)

1 (1.1)

3 (9.7)

0.050

2 (2.2)

2 (6.9)

0.239

No

118 (96.7)

90 (98.9)

28 (90.3)

 

91 (97.8)

27 (93.1)

 

Aspect ratio

       

≤ 1

36 (29.5)

30 (33)

6 (19.4)

0.151

28 (30.1)

8 (27.6)

0.795

> 1

86 (70.5)

61 (67)

25 (80.6)

 

65 (69.9)

21 (72.4)

 

Vascular invasion

       

Yes

6 (4.9)

3 (3.3)

3 (9.7)

0.156

3 (3.2)

3 (10.3)

0.145

No

116 (95.1)

88 (96.7)

28 (90.3)

 

90 (96.8)

26 (89.7)

 

TG (mean ± SD, ng/ml)

18.58 ± 55.16

9.63 ± 18.97

29.53 ± 93.52

0.065

10.25 ± 21.23

28.34 ± 93.97

0.321

TgAb (mean ± SD, IU/mL)

593.33 ± 912.61

642.05 ± 1028.16

824.56 ± 1047.04

0.400

693.65 ± 1033.38

678.26 ± 1045.54

0.945

Normal

30 (24.6)

24 (26.4)

6 (19.4)

0.433

22 (23.7)

8 (27.6)

0.668

High

92 (75.4)

67 (73.6)

25 (80.6)

 

71 (76.3)

21 (72.4)

 

TPOAb (mean ± SD, IU/mL)

181.61 ± 192.80

205.79 ± 214.10

127.23 ± 160.86

0.037*

200.60 ± 212.05

135.31 ± 168.36

0.140

Normal

44 (36.1)

29 (31.9)

15 (48.4)

0.098

30 (32.3)

14 (48.3)

0.117

High

78 (63.9)

62 (68.1)

16 (51.6)

 

63 (67.7)

15 (51.7)

 

FT3 (mean ± SD, pmol/L)

4.89 ± 0.79

5.05 ± 0.79

4.96 ± 0.60

0.576

5.00 ± 0.75

5.09 ± 0.74

0.585

FT4 (mean ± SD, pmol/L)

16.43 ± 3.07

17.00 ± 3.03

15.70 ± 2.68

0.037*

16.97 ± 3.12

15.71 ± 2.35

0.047*

TSH (mean ± SD, mIU/L)

2.85 ± 1.96

2.58 ± 1.86

2.81 ± 2.10

0.564

2.61 ± 1.84

2.72 ± 2.17

0.788

PTH (mean ± SD, pg/ml)

41.86 ± 36.95

38.78 ± 16.62

35.15 ± 15.47

0.319

39.97 ± 16.92

31.56 ± 12.75

0.020*

Leukocyte count (mean ± SD, 10^9/L)

5.78 ± 1.40

5.84 ± 1.33

5.79 ± 1.57

0.851

5.82 ± 1.36

5.85 ± 1.51

0.924

Erythrocyte count (mean ± SD, 10^12/L)

4.87 ± 8.02

4.47 ± 0.50

4.24 ± 0.51

0.027*

4.44 ± 0.49

4.30 ± 0.57

0.175

Hemoglobin (mean ± SD, g/L)

129.59 ± 15.79

131.34 ± 14.51

124.52 ± 14.96

0.027*

130.39 ± 14.82

127.10 ± 14.99

0.301

Platelet count (mean ± SD, 10^9/L)

215.27 ± 58.83

217.77 ± 57.19

203.68 ± 53.82

0.232

219.42 ± 57.93

197.41 ± 48.72

0.067

Vitamin D3 (mean ± SD, nmol/L)

20.48 ± 7.86

21.11 ± 8.04

19.24 ± 8.28

0.365

20.49 ± 8.55

20.76 ± 7.18

0.890

Serum Ca2+ (mean ± SD, mmol/L)

2.32 ± 0.15

2.34 ± 0.11

2.28 ± 0.13

0.033*

2.33 ± 0.11

2.29 ± 0.12

0.049*

  1. Note:
  2. Abbreviations: LNM, lymph node metastasis; CLNM, central lymph node metastasis; LLNM, lateral lymph node metastasis; TMD, tumor maximum diameter; Tumor location (L/R/I/B), tumor location (left/right/isthmus/bilateral); TG, thyroglobulin; TgAb, antithyroglobulin antibodies; TPOAb, thyroid peroxidase antibody; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid-stimulating hormone; PTH, parathyroid hormone.
  3. * Means P < 0.05.
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