Table 1 Clinical and radiological characteristics of patients, tumor characteristics, and methylation status from both training and validation sets.

From: AI tool for predicting MGMT methylation in glioblastoma for clinical decision support in resource limited settings

Feature

Description

Training

Validation

p-value

Tumor location

   

0.01

 

Type 1 (in contact with subventricular zone (SVZ) and cortex)

65(65)

21(45.7)

 
 

Type 2 (contact with SVZ but NOT cortex)

4(4)

6(13)

 
 

Type 3 (Contact ONLY with cortex)

31(31)

17(37)

 
 

NA

0(0)

2(4.3)

 

Laterality

   

0.33

 

Right

45(45)

16 (34.8)

 
 

Left

48(48)

24(52.2)

 
 

Bilateral

7(7)

6(13)

 

Well defined bordes

   

 < 0.01

 

Yes

18(18)

19(41.3)

 
 

No

82(82)

27(58.7)

 
 

NA

0(0)

0(0)

 

Multifocality

   

0.07

 

Yes

28(28)

9(19.6)

 
 

No

72(72)

35(76.1)

 
 

NA

0(0)

2(4.3)

 

Midline crossing

   

0.1

 

Yes

32(32)

13(28.3)

 
 

No

68(68)

31(67.4)

 
 

NA

0(0)

2(4.3)

 

Greatest dimension of contrast enhancing lesion

   

0.03

 < 1.5 cm

5(5)

3(6.5)

 

 ≥ 1.5 cm

95(95)

40(87)

 
 

NA

0(0)

3(6.5)

 

IDH 1/2 status

   

0.01

 

Wildtype

100(100)

42(91.3)

 
 

Mutated

0(0)

4(8.7)

 

Gender

   

0.02

 

Female

41(41)

29(63)

 
 

Male

59(59)

17(37)

 

MGMT status

   

0.7

 

Unmethylated

61(61)

30(65.2)

 
 

Methylated

39(39)

16(34.8)