Table 2 Associations of serum factor Bb level with progression of IMN patients. IMN, idiopathic membranous nephropathy; IQR, interquartile range; HR, hazard ratio; CI, confidence interval. Model 1 adjusted for age and sex (female and male, analyzed as dichotomous data). Model 2 adjusted for covariates in model 1 plus estimated glomerular filtration rate, proteinuria, PLA2R Ab, albumin and mean arterial pressure. Model 3 adjusted for covariates in model 2 plus Churg’s stages and TA/IF. Model 4 adjusted for covariates in model 3 plus immunosuppressants agents (yes or no, analyzed as dichotomous data). The disease progression event was defined as end-stage renal disease or ≥ 40% decline in estimated glomerular filtration rate. *Factor Bb was logarithmically transformed when treated as continuous trait. P values for trends were calculated by entering the median value of each tertile of factor Bb level as a continuous variable.
Unadjusted HR (95%CI) and P value | Adjusted HR (95%CI) and P value | ||||
|---|---|---|---|---|---|
Model 1 | Model 2 | Model 3 | Model 4 | ||
Log10 (Bb, ng/mL)* | 4.659 (3.046–7.127) < 0.001 | 4.528 (2.981–6.879) < 0.001 | 2.122 (1.343–3.353) 0.001 | 1.997 (1.244–3.206) 0.004 | 1.974 (1.227–3.176) 0.005 |
Factor Bb tertiles | |||||
Lowest tertile | Reference | Reference | Reference | Reference | Reference |
Middle tertile | 4.122 (2.271–7.483) < 0.001 | 3.997 (2.201–7.259) < 0.001 | 2.373 (1.264–4.453) 0.007 | 2.055 (1.077–3.923) 0.029 | 2.054 (1.076–3.920) 0.029 |
Highest tertile | 6.188 (3.500-10.943) < 0.001 | 6.523 (3.679–11.564) < 0.001 | 2.996 (1.621–5.536) < 0.001 | 2.616 (1.389–4.927) 0.003 | 2.592 (1.374–4.891) 0.003 |
P for trend | < 0.001 | < 0.001 | 0.001 | 0.006 | 0.007 |
