Table 9 Mediation effect of the pathway of pyrimidine deoxyribonucleoside degradation on GBS via HVEM on CM CD4 + /naive CD4 + /CD45RA- CD4 + /CM CD8br in the maturation stages of T cell panel.

From: Causal role of the pyrimidine deoxyribonucleoside degradation superpathway mediation in Guillain-Barré Syndrome via the HVEM on CD4 + and CD8 + T cells

Trait

Total effect (β)

Direct effect A (β)

Direct effect B (β)

Mediated effect (β)

Mediated Proportion (%)

HVEM on CM CD4 + 

-0.797

-0.393

0.101

-0.0398

5.00%

HVEM on naive CD4 + 

-0.797

-0.423

0.107

-0.0452

5.67%

HVEM on CD45RA- CD4 + 

-0.797

-0.364

0.114

-0.0414

5.19%

HVEM on CM CD8br

-0.797

-0.355

0.120

-0.0425

5.34%

  1. Total effect: The causal role of GM on GBS.
  2. Direct effect A: The causal role of GM on immune cell traits.
  3. Direct effect B: The causal role of immune cell traits on GBS.
  4. β(indirect effect) = β(Direct effect A)* β(Direct effect B).
  5. The mediated proportion = β(indirect effect)/β(total effect).
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