Table 3 Comparison with previous studies in DMD and FSHD.
From: Serum protein and imaging biomarkers after intermittent steroid treatment in muscular dystrophy
Dystrophy Increased (109 proteins) | Dystrophy Decreased (398 proteins) | Prednisone Increased (19 proteins) | Prednisone Decreased (69 proteins) | |
|---|---|---|---|---|
Hathout et al. 2019 | ||||
DMD Increased (112 proteins) | GPD1, YWHAE, CKM, MB, CKB|CKM, CA3, ANP32B, TNNT2, FABP3, TNNI2, ALDOA, MYBPC1 | ENO1, YWHAB, XRCC6, EIF4G2, YWHAH, HNRNPA2B1, YWHAZ, EIF4H | CKM, CKB|CKM, MYBPC1 | |
DMD Decreased (68 proteins) | IGFBP5, GDF11|MSTN, CNDP1, EHMT2 | ADIPOQ | ||
GC Increased (22 proteins) | FTCD | IGFBP5, SFTPD, ANXA1, CNDP1, S100A12 | MMP3, ANXA1 | |
GC Decreased (86 proteins) | VCAM1, CKM | DBNL | CCL22, CCL21, CSF1R, CKM, PTN, BGN, FCER2, THBS4, MMP12, IL22RA2 | |
Hathout et al. 2015 | ||||
DMD Elevated, Decreasing with Age (18 proteins) | CKM, MB, CA3, ANP32B, FABP3, TNNI2 | CKM | ||
DMD Decreased (15 proteins) | ||||
DMD Increased (6 proteins) | ||||
DMD Decreased, Decreasing with Age (5 proteins) | ||||
Dang et al. 2020 | ||||
DMD Positive Correlation with Severity (17 proteins) | ||||
DMD Negative Correlation with Severity (14 proteins) | SOD1, DYNLRB1 | |||
Parolo et al. 2018 | ||||
DMD Associated (50 proteins) | PLAT, CKM, MB, CKB|CKM, CA3, ANP32B, FABP3, TNNI2 | CKM, CKB|CKM | ||
Petek et al. 2016 | ||||
FSHD1 Increased (Seattle Cohort) (9 proteins) | CKB|CKM, CA3, FABP3, TNNI2 | CKB|CKM | ||
FSHD1 Decreased (Seattle Cohort) (24 proteins) | YWHAB, PDE5A, BTK, METAP1, CSK, LYN, CA13, FER, EIF4G2, PTPN6, PPID, PRKCB, DBNL | |||
FSHD1 Increased (Rochester Cohort) (21 proteins) | CKM, CKB|CKM, CA3, TNNI2 | BTK, C3, CSK, CA13, FER, EIF4G2, PDPK1, SHC1 | CKM, CKB|CKM | |
