Table 6 ADMET predicted profile for active compounds- metabolism.

Parameter	Corynoline	Magnoflorine	Neferine	Oxyacanthine	Columbamine	Berberine	Berbamine	Palmatine	Tranilast	Oridonin
GI absorption	High	High	High	High	High	High	High	High	High	High
BBB permeant	Yes	Yes	No	No	Yes	Yes	No	Yes	No	No
P-gp substrate	No	Yes	No	No	Yes	Yes	No	Yes	No	Yes
CYP1A2 inhibitor	Yes	Yes	No	No	Yes	Yes	No	No	No	No
CYP2C19 inhibitor	Yes	No	No	No	No	No	No	No	No	No
CYP2C9 inhibitor	No	No	No	No	No	No	No	No	Yes	No
CYP2D6 inhibitor	Yes	No	No	No	Yes	Yes	No	Yes	No	No
CYP3A4 inhibitor	Yes	Yes	No	No	Yes	Yes	No	Yes	No	No
Log Kp (skin permeation)	-6.62 cm/s	-6.44 cm/s	-5.35 cm/s	-5.51 cm/s	-5.94 cm/s	-5.87 cm/s	-5.51 cm/s	-5.79 cm/s	-6.02 cm/s	-8.47 cm/s

Quick links

Search