Table 9 Lipophilicity and water solubility of all the alkaloids in comparison to standard drugs.
Lipophilicity | Oxyacanthine | Neferine | Magnoflorine | Corynoline | Columbamine | Berberine | Berbamine | Palmatine | Tranilast | Oridonin |
|---|---|---|---|---|---|---|---|---|---|---|
Log Po/w (iLOGP) | 4.69 | 5.21 | -0.66 | 3.41 | -0.07 | -0.00 | 4.92 | 0.10 | 2.68 | 1.98 |
Log Po/w (XLOGP3) | 6.34 | 6.70 | 2.74 | 2.70 | 3.42 | 3.62 | 6.34 | 3.75 | 3.20 | 0.08 |
Log Po/w (WLOGP) | 5.45 | 5.35 | 2.31 | 1.65 | 3.08 | 3.10 | 5.45 | 3.38 | 2.75 | 0.38 |
LogPo/w (MLOGP) | 3.55 | 3.46 | -1.71 | 2.20 | 1.78 | 2.19 | 3.55 | 2.01 | 2.08 | 0.86 |
Log Po/w (SILICOS-IT) | 5.50 | 6.64 | 0.59 | 2.96 | 3.43 | 3.74 | 5.50 | 3.97 | 2.71 | 1.24 |
Consensus Log Po/w | 5.11 | 5.47 | 0.65 | 2.58 | 2.33 | 2.53 | 5.15 | 2.64 | 2.69 | 0.91 |
Water Solubility | ||||||||||
Log S (ESOL) | -7.80 | -7.66 | -3.91 | -4.15 | -4.37 | -4.55 | -7.80 | -4.58 | -3.79 | -2.15 |
Solubility | 9.54e-06 mg/ml ; 1.57e-08 mol/l | 1.36e-05 mg/ml ; 2.18e-08 mol/l | 4.19e-02 mg/ml ; 1.22e-04 mol/l | 2.61e-02 mg/ml ; 7.12e-05 mol/l | 1.45e-02 mg/ml ; 4.28e-05 mol/l | 9.53e-03 mg/ml ; 2.83e-05 mol/l | 9.54e-06 mg/ml ; 1.57e-08 mol/ | 9.30e-03 mg/ml ; 2.64e-05 mol/l | 5.27e-02 mg/ml ; 1.61e-04 mol/l | 2.58e + 00 mg/ml ; 7.08e-03 mol/l |
Class | Poorly soluble | Poorly soluble | soluble | Moderately soluble | Moderately soluble | Moderately soluble | Poorly soluble | Moderately soluble | Soluble | Soluble |
