Fig. 5
From: Optogenetic activation of serotonergic neurons changes masticatory movement in freely moving mice
5-HT2Areceptors are involved in induced fast masticatory movement by optogenetic activation of DRN 5-HT neurons. (a) Representative EMG recording of digastric and masseter muscles during voluntary mastication at 30 min after the administration of 0.3 mg/kg MDL100907 (s.c.) (left). Expanding EMG recordings in dotted box outlines of left EMG recordings (right). (b) Pooled data for masticatory frequency after yellow (control) or blue light (activation) application with the administration of MDL 100,907. (c) and (d) Pooled data for RMS peak amplitude (c) and duration (d) in masseter EMG bursts after yellow or blue light application with the administration of MDL 10,090. (e) and (f) Pooled data for RMS peak amplitude (e) and duration (f) in digastric EMG bursts after yellow or blue light application with the administration of MDL 100,907. Comparisons with n.s. have P > 0.05 and are considered not significant. Data are expressed as mean ± SEM.
