Fig. 6 | Scientific Reports

Fig. 6

From: Bioinformatics analysis to design a multi-epitope mRNA vaccine against S. agalactiae exploiting pathogenic proteins

Fig. 6

The four predicted conformational B-cell epitopes in the vaccine employing the ElliPro webserver. (I) Two-dimensional (2D) diagram of the discontinuous B-cell epitopes positions. (II) Three-dimensional (3D) structures of B-cell epitopes. The yellow-colored spheres illustrated the non-linear B-cell epitopes. (A) Conformational epitope contains 10 amino acids (AA 214–222, AA 383) with residue score of 0.736. (B) Conformational epitope contains 120 amino acids (AA 1, AA 5, AA 23–81, AA 83–95, AA 108–149, AA 151, AA 318, AA 320–321) with residue score of 0.708. (C) Conformational epitope contains 160 amino acids (AA 201, AA 205–210, AA 223–238, AA 240–257, AA 260–261, AA 269–277, AA 279–312, AA 340–357, AA 384–407, AA 410–423, AA 425–431, AA 449, AA 500–505, AA 509, AA 511, AA 515, AA 517) with residue score of 0.697. (D) Conformational epitope contains 37 amino acids (AA 519–529, AA 531–532, AA 539–543, AA 545–563) with residue score of 0.689.

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