Table 1 Patient characteristics and baseline of two groups.

From: Effect of metagenomic next-generation sequencing on clinical outcomes in adults with severe pneumonia post-cardiac surgery: a single-center retrospective study

 

mNGS (n = 53)

CMT (n = 60)

P-value

Age (yr)

58 (45, 68)

57 (48, 64)

0.6473

≥ 60, n (%)

21 (40)

22 (37)

0.7467

< 60, n (%)

32 (60)

38 (63)

Gender

   

Male, n (%)

35 (66)

37 (62)

0.6296

Female, n (%)

18 (34)

23 (38)

BMI

22.8 (21.2, 25.0)

23.3 (21.6, 25.3)

0.5539

APACHE II score before treatment

26(23, 29.5)

24(21,28.75)

0.0362

SOFA score before treatment

9.981 ± 2.839

8.983 ± 2.318

0.0422

VIS

28 (19, 30)

18 (10.5, 30)

0.0174

Types of cardiac surgery

   

Heart Valve Surgery

29(55)

35(58)

0.6987

Coronary Artery Bypass Grafting

16(30)

20(33)

0.7203

Aortic Surgery

11(21)

11(18)

0.7456

Congenital Heart Defect Repair

3(6)

5(8)

0.5804

Implantation of Assistive Devices

3(6)

0(0)

0.0618

Heart Transplantation

3(6)

0(0)

0.0618

Duration of surgery

424.6 ± 150.6

409 ± 133.8

0.5627

CPB time

199.0 (174.3, 296.0)

192.5 (167.0, 291.3)

0.4426

Aortic cross-clamp time

116.0 (100.0, 159.5)

110.0 (90.0, 142.5)

0.4537

Laboratory examination before treatment†

   

WBC (109/L)

16.0 (12.9, 18.3)

14.5 (8.6, 17.0)

0.1377

Percentage of neutrophils (%)

88.7 (85.0, 92.0)

85.4 (80.0, 90.3)

0.0173

PCT (ng/mL)

9.1 (5.0, 23.1)

10.2 (3.8, 17.7)

0.6089

CRP (mg/L)

157.7 (149.4, 173.9)

152.6 (116.3, 162.3)

0.0576

Scr (µmol/L)

110.9 (95.20, 158.5)

109.2 (85.80, 142.8)

0.2812

ALT (U/L)

45.0 (30.5, 117.5)

39.5 (25.3, 96.0)

0.2562

Lactate (mmol/L)

4.3 (1.9, 8.4)

3.7 (1.5, 7.5)

0.3227

Ventilator parameters

   

FiO2 (%)

60 (50, 65)

50 (40, 50)

0.0003

PEEP

9 (8, 10)

8 (6, 8)

0.0006

Oxygenation Index

184.5 ± 39.5

206.0 ± 47.6

0.0108

  1. †"Before treatment” refers to the period after the patient was transferred to the ICU but before receiving empirical antibiotic therapy. mNGS, metagenomic next-generation sequencing; CMT, conventional microbiological test; BMI, body mass index; APACHE II score, Acute Physiology and Chronic Health Evaluation-II score; SOFA score, Sequential Organ Failure Assessment score; VIS, vasoactive inotropic score; CPB, cardiopulmonary bypass; WBC, white blood cell; PCT, procalcitonin; CRP, C-reactive protein; Scr, serum creatinine; ALT, alanine aminotransferase; FiO2, fraction of inspiration O2; PEEP, Positive end expiratory pressure.
  2. Data reported as number and percentage, mean ± standard deviation or median (interquartile range). P values of < 0.05 were considered to denote the statistical significance.
  3. Values in bold indicated statistical differences between the two groups.
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