Table 2 The etiology results and treatment of patients in mNGS and CMT groups.

From: Effect of metagenomic next-generation sequencing on clinical outcomes in adults with severe pneumonia post-cardiac surgery: a single-center retrospective study

 

mNGS

CMT

P-value

Time of sample submission to results feedback (hours)

22 (18.0, 24.5)

67 (56.5, 83.0)

< 0.0001

The overall positive rate (n, %)

52 (98)

35 (58)

< 0.0001

Antibiotic adjustments (n, %)

33 (62)

20 (33)

0.0021

The antibiotics were de-escalated or simplified

8 (15)

2(3)

0.0280

New antibiotics were added or the current antibiotics were upgraded

25 (47)

15 (25)

0.0139

  1. mNGS, metagenomic next-generation sequencing; CMT, conventional microbiological test.
  2. Data reported as number and percentage, mean ± standard deviation or median (interquartile range). P values of < 0.05 were considered to denote the statistical significance.
  3. Values in bold indicated statistical differences between the two groups.
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