Table 1 Key Mpox virulence factors with the highest degree of centrality (> 15) in HPI models.
Protein name (Uniprot IDs) | Organism | Degree | Predicted motif/function | Role in virulence | Reference |
|---|---|---|---|---|---|
D11L (Q8V565) | Mpox | 52 | Bcl-2 domain, IFN-β inhibitor | Inhibits signaling from IFN regulatory factor 3 | |
D9L (Q8V567) | Mpox | 43 | Ankyrin repeat protein OPG025 | Counteracts interferons during viral replication | |
F7R (Q8V524) | Mpox | 27 | ER localized MP | ER localized MP | |
C6R (Q8V548) | Mpox | 25 | Putative TLR signaling inhibitor | Inhibits pro-inflammatory and apoptotic processes | |
P2L (Q8V556) | Mpox | 25 | α-Amanitin sensitivity (N2L) | Bcl-2 domain, IRF3 activation inhibitor, α-amanitin target | |
EGFR (P00533) | Human | 23 | Tyrosine protein kinase, EGF/ERB/XmrK receptor | Promotes DNA synthesis and cell proliferation via MAPK, Akt, and JNK pathways | |
F3L (Q8V528) | Mpox | 22 | PKR/OAS inhibitor | Z-DNA and dsRNA binding domain | |
C18L (Q8V536) | Mpox | 19 | NA | Promotes wrapped virion trafficking | |
G7R (Q8V505) | Mpox | 19 | NA | NA | |
J2L (Q77HM5) | Mpox | 19 | NA | Secreted TNF binding protein | |
TRAF6 (B6CJY4) | Human | 18 | TNF receptor-associated factor TRAF | Activates IKK in cytokine response via NF-kappaB pathway | |
UBC (P0CG48) | Human | 17 | Polyubiquitin-C | Innate immunity, DNA repair, and kinase activity | |
B12R (Q8V4R6) | Mpox | 15 | Serpin (SPI-2/apoptosis) | Serine protease inhibitor |
