Table 2 Enriched analysis of antiviral/proviral genes and upstream signals.

From: Exploration of drug repurposing for Mpox outbreaks targeting gene signatures and host-pathogen interactions

Description

Category

ID

Count

p

Cytokine signaling in immune system

Reactome

R-HSA-1,280,215

78

8.02E-35

Immune system

Reactome

R-HSA-168,256

114

1.60E-29

Interferon signaling

Reactome

R-HSA-913,531

40

2.29E-23

TRIF(TICAM1)-mediated TLR4 signaling

Reactome

R-HSA-937,061

26

3.80E-20

MyD88-independent TLR4 cascade

Reactome

R-HSA-166,166

26

3.80E-20

Innate immune system

Reactome

R-HSA-168,249

67

2.89E-18

MyD88 dependent cascade initiated on endosome

Reactome

R-HSA-975,155

23

3.87E-17

PIP3 activates AKT signalling

Reactome

R-HSA-1,257,604

85

1.26E-15

Apoptotic process

GO term

GO:0006915

40

2.05E-15

Lipopolysaccharide-mediated signaling pathway

GO term

GO:0031663

14

9.00E-15

Positive regulation of I-kappaB kinase/NF-kappaB signalling

GO term

GO:0043123

22

1.02E-12

Regulation of transcription, DNA-templated

GO term

GO:0045892

32

2.06E-10

Inflammatory response

GO term

GO:0006954

27

4.41E-10

Negative regulation of cell proliferation

GO term

GO:0008285

22

2.01E-06

Signal transduction

Reactome

R-HSA-162,582

81

4.65E-06

Protein phosphorylation

GO term

GO:0006468

31

0.004428