Table 1 Statistics corresponding to Fig. 1. Litter sizes, age at first litter, days to first litter, and litter frequency were analyzed using ordinary one-way ANOVA with post hoc Tukey’s multiple comparisons. Litter sizes over time was analyzed using repeated measures two-way ANOVA with post hoc Tukey’s multiple comparisons between genotypes at each litter. Significance was set at p < 0.05 for all datasets. All significant results are in bold.

1d

Litter sizes

F (2, 94) = 31.77

p < 0.0001

WT vs. LKB1^fl/fl

p = 0.1159

WT vs. Na_v1.8^LKB1

p < 0.0001

LKB1^fl/flvs. Na_v1.8^LKB1

p < 0.0001

1e

Litter sizes over time

Litter: F (2.707, 43.31) = 3.683

p = 0.0223

Litter 1: WT vs. LKB1^fl/fl

p = 0.2963

Genotype: F (2, 18) = 15.63

p = 0.0001

Litter 1: WT vs. Na_v1.8^LKB1

p = 0.0203

Litter x Genotype: F (8, 64) = 0.3204

p = 0.9554

Litter 1: LKB1^fl/fl vs. Na_v1.8^LKB1

p = 0.1047

Litter 2: WT vs. LKB1^fl/fl

p = 0.4278

Litter 2: WT vs. Na_v1.8^LKB1

p = 0.0807

Litter 2: LKB1^fl/fl vs. Na_v1.8^LKB1

p = 0.2280

Litter 3: WT vs. LKB1^fl/fl

p = 0.2248

Litter 3: WT vs. Na_v1.8^LKB1

p = 0.0224

Litter 3: LKB1^fl/fl vs. Na_v1.8^LKB1

p = 0.1166

Litter 4: WT vs. LKB1^fl/fl

p = 0.5085

Litter 4: WT vs. Na_v1.8^LKB1

p = 0.0469

Litter 4: LKB1^fl/fl vs. Na_v1.8^LKB1

p = 0.0982

Litter 5: WT vs. LKB1^fl/fl

p = 0.7226

Litter 5: WT vs. Na_v1.8^LKB1

p = 0.0298

Litter 5: LKB1^fl/fl vs. Na_v1.8^LKB1

p = 0.0683

1f

Age at first litter

F (2, 29) = 9.040

p = 0.0009

WT vs. LKB1^fl/fl

p = 0.9537

WT vs. Na_v1.8^LKB1

p = 0.0021

LKB1^fl/flvs. Na_v1.8^LKB1

p = 0.0036

1 g

Days to first litter

F (2, 23) = 2.265

p = 0.1266

n/a

1 h

Litter frequency

F (2, 58) = 2.974

p = 0.0590

n/a