Table 5 Selected plasma lipid metabolites from dogs consuming extruded canine diets with different protein sources.

Metabolite, fold change

CLHd/

CONd

CHd/

CONd

CLHd/

CONd

q-value

CHd/

CONd

q-value

Eicosapentaenoate (EPA; 20:5n3)

2.78

0.87

0.72

0.0014

0.69

0.0188

Docosapentaenoate (DPA; 22:5n3)

2.94

1.16

0.77

0.0030

0.72

0.0521

Docosahexaenoate (DHA; 22:6n3)

3.33

1.06

1.82

0.0005

0.98

0.4106

Arachidonate (20:4n6)

2.56

1.01

1.20

0.0043

0.97

0.3092

Osbond acid (22:5n6)

2.13

1.03

1.56

0.0004

1.11

0.1644

Sphinganine

2.38

1.30

1.19

0.0085

1.30

0.0008

N-stearoyl-sphingosine (d18:1/18:0)

1.82

2.17

1.64

0.0003

2.22

0.0001

Lactosyl-N-nervonoyl-sphingosine (d18:1/24:1)

-

-

1.16

0.0032

1.03

0.3961

Stearoyl sphingomyelin (d18:1/18:0)

0.27

1.45

1.35

< 0.0001

1.37

0.0001

Sphingosine

12.50

2.27

1.19

0.0003

1.20

0.0397

Sphingosine-1-phosphate

-

-

1.10

0.0304

1.08

0.1443

Ceramide (d18:1/17:0, d17:1/18:0)

2.33

1.61

1.33

0.0048

1.52

0.0028

Cholesterol

2.94

1.49

1.27

0.0014

1.20

0.0305

Cholate

0.15

0.09

1.02

0.1822

0.22

0.0372

Chenodeoxycholate

0.36

0.12

1.33

0.0658

0.20

0.0028

Taurochenodeoxycholate

1.41

0.33

2.70

0.2296

0.37

0.0153

Beta-muricholate

-

-

0.77

0.1280

0.22

0.0207

Tauro-alpha-muricholate

-

-

0.67

0.0530

0.18

0.0068

Ursocholate

0.28

0.28

0.68

0.0578

0.29

0.0411

Ursodeoxycholate

1.00

1.00

1.11

0.0991

0.11

0.0268

Tauroursodeoxycholate

2.27

0.26

0.70

0.0138

0.28

0.0046

12-dehydrocholate

0.17

0.07

0.77

0.1703

0.22

0.0304

7-ketodeoxycholate

0.26

0.08

0.92

0.1488

0.19

0.0271