Fig. 1

Study design for the Chinese cohort (Subset of STOP-HCC-MCE) (A) and baseline disease characteristics (B,C). *Reasons for exclusion were: missing required laboratory parameter data (n = 37); GFR < 60 mL/min/1.73 m2 (n = 19); other cancer diagnosis (n = 11); non-confirmed diagnosis (n = 8); incomplete/incorrect sample processing (n = 4); current/previous treatment with anti-vitamin K coagulant therapy (n = 3); written informed consent not obtained (n = 2); sponsor decision (n = 2) and recurrent HCC (n = 1). †Participants were excluded due to low number of samples (n < 5).