Fig. 3

Foxp3 + Tregs-derived IL-10 promotes CRC-derived lung metastasis. (A) Schematic overview of lung metastasis induction following MC38 colon cancer cell intravenous injection in mice harboring Foxp3 + Treg cell-specific Il10 deletion and respective controls (n ≥ 6 mice per group). (B) Representative images and number of macroscopic lung metastases. Scale bar: 2 mm. Data are presented as mean ± SEM. **p ≤ 0.01, as calculated by Mann–Whitney U test.