Fig. 5
From: Foxp3 + Treg-derived IL-10 promotes colorectal cancer-derived lung metastasis
IL-10 signaling in Foxp3 + Tregs and myeloid cells promotes lung metastasis. (A) Schematic overview of forced lung metastasis induction in mice with cell-specific Il10ra deletion (n ≥ 6 mice per group). (B,C) Representative images and number of lung metastases in mice with (B) Treg−, or (C) myeloid cell-specific Il10ra deletion. Scale bar: 2 mm. Data are presented as mean ± SEM. Non-significant (ns): p > 0.05; *p < 0.05; **p ≤ 0.01; as calculated by Mann–Whitney U test.
