Fig. 8 | Scientific Reports

Fig. 8

From: A computational model that integrates unrestricted callus growth, mechanobiology, and angiogenesis can predict bone healing in rodents

Fig. 8

(A) Temporal analysis of tissue volume formation post-fracture. Presents daily tissue formation volumes within a designated region up to day 21 post-surgery, as quantified from model simulations. The result demonstrates the model’s ability to replicate hematoma formation and transformation of tissue types together as the healing progresses. Comparing it to histological data from Fig. 7 highlights the correlation in timing and quantity of hematoma, granulation tissue, cartilage, and new osteogenesis. (B) The spatial and temporal tissue formation and differentiation trend in the model after fracture specified to match the coloring in part A.

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