Table 3 Univariate analysis of prognostic factors for overall survival and progression-free survival of Burkitt lymphoma.

From: Survival of HIV associated diffuse large B-cell lymphoma and Burkitt lymphoma in China

 

Overall survival

Progression free survival

 

HR (95% CI) from Cox regression

p-value from log rank test

HR (95% CI) from Cox regression

p-value from log rank test

Age > 60

25.882 (0.018, 36834.702)

0.380

25.780 (0.008, 82277.338)

0.430

High Risk IPI

0.039 (0.000, 1099.400)

0.534

0.039 (0.000, 3454.451)

0.576

ECOG PS > 1

0.332 (0.046, 2.411)

0.276

0.236 (0.030, 1.849)

0.169

Number of extranodal sites ≥ 2

0.119 (0.005, 2.775)

0.185

0.091 (0.003, 2.746)

0.168

Bulky disease

0.278 (0.018, 4.243)

0.357

0.483 (0.043, 5.391)

0.554

B symptoms

10.068 (1.923, 52.715)

0.006

8.733 (1.429, 53.348)

0.019

Bone marrow involvement

0.302 (0.034, 2.700)

0.284

0.163 (0.012, 2.228)

0.174

Elevated LDH

30.608 (0.020, 46159.610)

0.360

18.037 (0.013, 24985.425)

0.433

CNS Involvement

10.548 (0.699, 159.127)

0.089

70.715 (1.620, 3087.164)

0.027

CD4 count < 100/µL

12.485 (2.443, 63.800)

0.002

8.231 (1.916, 35.356)

0.005

Rituximab use

0.420 (0.040, 4.415)

0.470

0.575 (0.050, 6.550)

0.655

  1. Abbreviations: CNS, central nervous system; ECOG PS, Eastern Cooperative Oncology Group Performance Status; IPI, International Prognostic Index; LDH, lactate dehydrogenase.