Table 2 Anti-factor xa activity and ClotPro values for samples spiked with low molecular weight heparin.
From: Detection of enoxaparin and argatroban by use of the novel viscoelastic coagulometer ClotPro
Reference range | CON = 0 N = 12 | CON = 0.25 N = 12 | CON = 0.5 N = 12 | CON = 0.75 N = 12 | CON = 1 N = 12 | r | |
|---|---|---|---|---|---|---|---|
Anti-factor Xa activity (IU.ml− 1) | < 0.1 | < 0.1 (< 0.1-<0.1) | 0.18 (0.15–0.18) | 0.41 (0.38–0.43) | 0.59 (0.54–0.62) | 0.82 (0.74–0.84) | - |
Clotting time (s) | 48–77 | 61 ± 8 | 77 ± 17 | 112 ± 24 | 142 ± 36 | 172 ± 47 | 0.88 (95% CI 0.8–0.92; p < 0.001) |
Clot formation time (s) | 63 ± 14 | 65 ± 16 | 68 ± 18 | 72 ± 18 | 75 ± 18 | 0.32 (95% CI 0.08–0.53; p = 0.01) | |
Amplitude after 5 min (mm) | 38–55 | 45.3 ± 4.9 | 45.2 ± 5.2 | 44.8 ± 5.1 | 44.2 ± 5.0 | 43.3 ± 5.2 | -0.22 (95% CI -0.45-0.03; p = 0.09) |
Amplitude after 10 min (mm) | 47–63 | 53.4 ± 4.5 | 53.3 ± 4.7 | 53.2 ± 4.6 | 52.6 ± 4.6 | 51.8 ± 4.7 | -0.2 (95% CI -0.43-0.05; p = 0.12) |
Amplitude after 20 min (mm) | 53–67 | 57.6 ± 4.2 | 57.2 ± 4.5 | 57.3 ± 4.2 | 56.9 ± 4.2 | 56.6 ± 4.1 | -0.16 (95% CI -0.39-0.1; p = 0.24) |
Amplitude after 30 min (mm) | 57.9 ± 4.2 | 57.0 ± 4.7 | 57.5 ± 4.1 | 57.0 ± 4.2 | 57.0 ± 3.9 | -0.14 (95% CI -0.38-0.12; p = 0.29) | |
Maximum clot firmness (mm) | 54–68 | 58.3 ± 4.2 | 57.6 ± 4.4 | 58.0 ± 3.9 | 57.4 ± 3.9 | 57.4 ± 3.8 | -0.15 (95% CI -0.39-0.11; p = 0.27) |
