Table 3 Diluted thrombin time, activated partial thromboplastin time and ClotPro values for samples spiked with argatroban.
From: Detection of enoxaparin and argatroban by use of the novel viscoelastic coagulometer ClotPro
Reference range | CON = 0 N = 12 | CON = 0.25 N = 12 | CON = 0.5 N = 12 | CON = 0.75 N = 12 | CON = 1 N = 12 | r1 | r2 | |
|---|---|---|---|---|---|---|---|---|
Diluted thrombin time (s) | < 0.1 | 0.00 (0.00–0.00) | 0.26 (0.25–0.27) | 0.54 (0.53–0.56) | 0.82 (0.81–0.89) | 1.13 (1.07–1.18) | - | - |
Activated partial thromboplastin time (s) | 27–41 | 35 ± 2 | 53 ± 3 | 62 ± 4 | 70 ± 5 | 76 ± 5 | - | - |
Clotting time (s) | 68–100 | 79 ± 6 | 230 ± 12 | 318 ± 18 | 420 ± 28 | 483 ± 31 | 0.97 (95% CI 0.96–0.98; p < 0.001) | 0.96 (95% CI 0.93–0.97; p < 0.001) |
Clot formation time (s) | 74 ± 8 | 102 ± 16 | 133 ± 25 | 147 ± 16 | 170 ± 28 | 0.84 (95% CI 0.75–0.9; p < 0.001) | 0.8 (95% CI 0.68–0.87; p < 0.001) | |
Amplitude after 5 min (mm) | 45–48 | 48.9 ± 4.7 | 47.6 ± 4.5 | 43.8 ± 4.7 | 42.9 ± 3.4 | 39.0 ± 4.4 | -0.65 (95% CI -0.77–0.47; p < 0.001) | -0.59 (95% CI -0.73–0.39; p < 0.001) |
Amplitude after 10 min (mm) | 54–66 | 56.7 ± 4.2 | 56.5 ± 4.4 | 55.2 ± 5.2 | 56.0 ± 4.2 | 55.0 ± 3.5 | -0.17 (95% CI -0.41-0.08; p = 0.19) | -0.17 (95% CI -0.4-0.09; p = 0.21) |
Amplitude after 20 min (mm) | 58- -70 | 61.4 ± 3.5 | 61.1 ± 3.6 | 60.2 ± 4.7 | 61.0 ± 3.7 | 61.0 ± 3.8 | -0.07 (95% CI -0.32-0.19; p = 0.6) | -0.08 (95% CI -0.33-0.18; p = 0.56) |
Amplitude after 30 min (mm) | 62.8 ± 3.3 | 62.5 ± 3.3 | 61.1 ± 4.3 | 62.3 ± 3.6 | 62.1 ± 3.9 | -0.1 (95% CI -0.36-0.17; p = 0.46) | -0.12 (95% CI -0.37-0.15; p = 0.39) | |
Maximum clot firmness (mm) | 61–72 | 63.2 ± 3.2 | 62.8 ± 3.1 | 61.9 ± 4.1 | 62.6 ± 3.3 | 62.5 ± 3.5 | -0.1 (95% CI -0.34-0.16; p = 0.45) | -0.11 (95% CI -0.36-0.14; p = 0.39) |
