Table 3 Lab and neurodiagnostic abnormality associations with disease severity.

From: Diagnostic abnormalities, disease severity and immunotherapy responsiveness in individuals with Down syndrome regression disorder

 

Catatonia

p value [95%CI]

BFCRS ≥ 20

p value [95%CI]

NPI-QSS ≥ 10

p value [95%CI]

History of Autoimmune Disease

0.87

[0.33–1.87]

0.74

[0.27–2.09]

0.61

[0.64–1.49]

C3 Abnormal

0.31

[0.64–2.34]

0.36

[0.74–1.67]

0.22

[0.86–2.11]

C4 Abnormal

0.41

[0.51–1.69]

0.48

[0.53–1.88]

0.67

[0.39–1.91]

ANA Abnormal

0.55

[0.34–2.36]

0.43

[0.42–1.69]

0.53

[0.57–1.55]

TPO Abnormal

0.69

[0.70–1.36]

0.73

[0.77–2.01]

0.42

[0.64–1.23]

Thyroglobulin Abnormal

0.38

[0.31–1.77]

0.50

[0.29–1.34]

0.27

[0.48–1.54]

CRP Abnormal

0.44

[0.19–1.64]

0.67

[0.63–2.97]

0.09

[0.98–2.13]

ESR Abnormal

0.21

[0.81–1.46]

0.33

[0.72–1.59]

0.14

[0.93–1.11]

Ferritin Abnormal

0.67

[0.66–1.47]

0.39

[0.81–1.34]

0.48

[0.72–1.79]

Cytokines Abnormal

0.42

[0.39–2.47]

0.61

[0.81–3.49]

0.37

[0.71–5.69]

EEG Abnormal

0.79

[0.29–6.31]

0.87

[0.20–6.66]

0.19

[0.35–2.42]

MRI Abnormal

0.02

[1.13–2.35]

0.04

[1.36–2.49]

0.11

[0.89–1.87]

LP Abnormal

0.03

[1.34–3.46]

0.03

[1.09–2.97]

< 0.001

[2.63–4.69]

MRI and LP Abnormal

0.01

[1.87–3.98]

0.02

[1.63–3.65]

0.02

[1.43–3.07]

EEG, MRI, and LP Abnormal

0.09

[0.77–3.41]

0.16

[0.63–2.01]

0.03

[1.09–3.06]

  1. Legend: Antinuclear antibody (ANA), Bush-Francis Catatonia Rating Scale (BFCRS), complement (C), cerebrospinal fluid (CSF), C-reactive protein (CRP), electroencephalogram (EEG), immunoglobulin G (IgG), lumbar puncture (LP), magnetic resonance imaging (MRI), Neuropsychiatric Inventory Questionnaire Severity Score (NPI-QSS), oligoclonal band (OCB), thyroid peroxidase. All values presented as p value [95% confidence interval]. Bolded items indicate a p-value < 0.05.
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