Table 4 Lab and diagnostic abnormalities associated with immunotherapy responsiveness.
Immunotherapy Responsiveness* When Feature Present | Immunotherapy Responsiveness* When Feature Absent | p Value | 95% CI | Odds Ratio | |
|---|---|---|---|---|---|
DSRD Criteria (probable v. possible) | 79/109 (72%) | 39/55 (71%) | 0.83 | 0.80–1.31 | 1.03 |
History of Autoimmune Disease | 63/85 (74%) | 55/79 (70%) | 0.53 | 0.79–1.58 | 1.12 |
Catatonia Present | 93/123 (75%) | 26/41 (63%) | 0.13 | 0.84–3.81 | 1.79 |
C3 Abnormal | 39/48 (81%) | 78/116 (67%) | 0.07 | 0.93–4.80 | 2.11 |
C4 Abnormal | 31/40 (78%) | 86/124 (69%) | 0.32 | 0.66–3.51 | 1.52 |
ANA Abnormal | 29/48 (60%) | 89/116 (77%) | 0.04 | 0.23–0.95 | 0.46 |
TPO Abnormal | 39/56 (70%) | 78/108 (72%) | 0.73 | 0.43–1.79 | 0.88 |
Thyroglobulin Abnormal | 32/46 (70%) | 85/118 (72%) | 0.75 | 0.42–1.87 | 0.89 |
CRP Abnormal | 5/7 (71%) | 113/157 (72%) | 0.97 | 0.18–5.20 | 0.97 |
ESR Abnormal | 24/29 (83%) | 93/135 (69%) | 0.14 | 0.77–6.07 | 2.17 |
Ferritin Abnormal | 22/27 (81%) | 96/137 (70%) | 0.23 | 0.67–5.30 | 1.88 |
Cytokines Abnormal | 46/54 (85%) | 60/88 (68%) | 0.03 | 1.12–6.43 | 2.68 |
EEG Abnormal | 38/49 (77%) | 79/115 (69%) | 0.25 | 0.72–3.43 | 1.57 |
MRI Abnormal | 47/53 (87%) | 59/111 (62%) | < 0.001 | 3.15–20.17 | 7.98 |
LP Abnormal | 30/34 (88%) | 88/130 (68%) | 0.02 | 1.18–10.82 | 3.58 |
MRI and LP Abnormal | 20/21 (95%) | 59/96 (61%) | 0.01 | 1.75–105.1 | 13.56 |
EEG, MRI, and LP Abnormal | 15/16 (94%) | 44/76 (58%) | 0.02 | 1.37–86.87 | 10.91 |
