Table 1 Papp and ER values of five flavonoids in HLF across Caco-2 cell monolayer. Data are represented as mean ± SD, n = 3.

From: Gastrointestinal absorption and its regulation of hawthorn leaves flavonoids

Flavonoids

Concentration

(µg·mL−1)

Receiver chamber

ER

Papp (AP→BL)

×10−7 (cm·sec−1)

Papp (BL→AP)

×10−7 (cm·sec−1)

GLV

50

2.18 ± 0.15

2.29 ± 0.18

1.05

100

2.70 ± 0.24***

3.28 ± 0.24***

1.21

200

2.58 ± 0.18**

3.27 ± 0.37***

1.27

RHV

50

2.21 ± 0.23

1.54 ± 0.26

0.70

100

2.78 ± 0.33***

3.24 ± 0.26***

1.17

200

2.69 ± 0.19**

2.95 ± 0.27***###

1.10

VIT

50

2.54 ± 0.26

2.83 ± 0.12

1.11

100

3.16 ± 0.27***

4.34 ± 0.35***

1.37

200

3.22 ± 0.12***

4.11 ± 0.49***##

1.28

RUT

50

2.28 ± 0.27

2.45 ± 0.15

1.07

100

3.04 ± 0.22***

3.39 ± 0.14***

1.12

200

2.93 ± 0.38***

3.42 ± 0.27***

1.17

HP

50

2.56 ± 0.24

3.23 ± 0.12

1.26

100

3.83 ± 0.22***

5.61 ± 0.46***

1.46

200

3.49 ± 0.39***##

5.45 ± 0.43***#

1.56

  1. Concentration of HLF in the transport medium were 50, 100 and 200 µg·mL−1, respectively. *p < 0.05, **p < 0.01 and ***p< 0.001 compared to 50 µg·mL−1 group; #p < 0.05, ##p < 0.01 and ###p< 0.001 compared to 100 µg·mL−1 group.
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