Fig. 4

CNV profiles based on cfRRBS data show aberrations in plasma samples with tumor fractions above 15%. (A) CNV profile of ID25_EAC_4, showing a focal gain/amplification in chromosome 8; (B) CNV profile of ID48_EAC_4, showing a focal gain/amplification in chromosome 12; (C) CNV profile of ID55_EAC_3, showing a focal gain/amplification in chromosome 7; (D) complete CNV profile of ID58_EAC_0 and a zoomed in profile of chromosome 1. The profile of this patient blood sample collected at the time of diagnosis showed a focal gain/amplification in chromosome 1.