Table 1 Burden (incidence) of testicular cancer in adolescents and young adults and their temporal trends from 1990 to 2021, using Joinpoint analysis.

From: Global burden and trends of testicular cancer in adolescents and young adults from 1990 to 2021, with predictions to 2035

Characteristics

Number of cases, 1990 (95% UI)

Age-standardized rate per 100,000 population, 1990 (95% CI)

Number of cases, 2021 (95% UI)

Age-standardized rate per 100,000 population, 2021 (95% CI)

AAPC (Age-standardized rate, 95% CI)

p

Global

28,499 (27,000–30,124)

2.64 (2.50–2.79)

61,596 (57,749–66,175)

4.05 (3.80–4.35)

1.37 (0.99 to 1.76)

< 0.001

High SDI

16,470 (15,350–17,668)

9.06 (8.45–9.72)

21,798 (20,201–23,544)

11.38 (10.55–12.3)

0.82 (0.26 to 1.39)

0.0041

High-middle SDI

7005 (6245–7970)

3.04 (2.71–3.45)

17,345 (14,796–20,701)

7.3 (6.19–8.76)

2.97 (2.72 to 3.23)

< 0.001

Middle SDI

3099 (2860–3370)

0.84 (0.78–0.91)

15,045 (13,643–16,472)

3.16 (2.87–3.46)

4.37 (4.1 to 4.65)

< 0.001

Low-middle SDI

1450 (1157–1778)

0.68 (0.54–0.83)

5655 (4799–6693)

1.42 (1.21–1.69)

2.42 (2.27 to 2.58)

< 0.001

Low SDI

434 (296–581)

0.52 (0.36–0.69)

1677 (1322–2078)

0.82 (0.64–1.01)

1.46 (1.38 to 1.54)

< 0.001

High-income Asia Pacific

1854 (1421–2402)

5.47 (4.19–7.08)

1771 (1386–2163)

6.49 (5.08–7.91)

0.62 (−0.78 to 2.04)

0.3855

High-income North America

5873 (5447–6346)

9.87 (9.16–10.67)

9210 (8403–10125)

14.47 (13.2–15.91)

1.4 (0.58 to 2.22)

< 0.001

Western Europe

9192 (8232–10265)

12.27 (10.99–13.7)

9933 (8623–11509)

14.44 (12.54–16.74)

0.61 (−0.23 to 1.46)

0.1555

Australasia

566 (422–749)

13.71 (10.22–18.16)

872 (600–1203)

15.77 (10.86–21.75)

0.61 (0.15 to 1.07)

0.0093

Eastern Europe

1578 (1421–1761)

3.55 (3.2–3.95)

2644 (2365–2933)

7.11 (6.36–7.9)

2.52 (1.48 to 3.56)

< 0.001

Central Europe

1896 (1677–2162)

7.92 (7.01–9.04)

3229 (2744–3788)

17.18 (14.6–20.16)

2.74 (2.27 to 3.2)

< 0.001

Southern Latin America

654 (493–857)

7.02 (5.3–9.18)

2756 (2089–3596)

20.93 (15.86–27.33)

3.69 (2.8 to 4.59)

< 0.001

East Asia

1215 (996–1464)

0.43 (0.35–0.52)

3398 (2609–4453)

1.27 (0.97–1.67)

3.64 (2.87 to 4.41)

< 0.001

Central Asia

191 (152–247)

1.37 (1.09–1.76)

443 (362–548)

2.25 (1.84–2.79)

1.52 (1.01 to 2.03)

< 0.001

North Africa and Middle East

1430 (921–2220)

2.18 (1.41–3.37)

9121 (6880–12391)

6.87 (5.17–9.35)

3.78 (3.48 to 4.07)

< 0.001

Andean Latin America

107 (68–167)

1.47 (0.93–2.28)

740 (486–1080)

5.38 (3.53–7.85)

4.24 (3.39 to 5.11)

< 0.001

Southeast Asia

550 (444–683)

0.59 (0.48–0.73)

1981 (1514–2560)

1.39 (1.06–1.8)

2.76 (2.58 to 2.95)

< 0.001

Tropical Latin America

417 (367–478)

1.35 (1.19–1.54)

2263 (1939–2633)

5.09 (4.36–5.92)

4.65 (4.4 to 4.91)

< 0.001

Southern Sub-Saharan Africa

64 (49–81)

0.66 (0.5–0.82)

178 (141–221)

1.04 (0.83–1.29)

1.32 (0.79 to 1.84)

< 0.001

Caribbean

24 (19–31)

0.34 (0.27–0.43)

193 (147–251)

2.11 (1.61–2.74)

6.11 (3.94 to 8.32)

< 0.001

Central Latin America

783 (720–849)

2.41 (2.22–2.61)

5372 (4764–6048)

10.79 (9.57–12.15)

4.98 (4.41 to 5.55)

< 0.001

South Asia

1828 (1460–2240)

0.87 (0.7–1.06)

6228 (5130–7475)

1.56 (1.29–1.88)

1.9 (1.73 to 2.06)

< 0.001

Central Sub-Saharan Africa

35 (21–55)

0.36 (0.22–0.57)

155 (91–251)

0.61 (0.36–0.99)

1.74 (1.56 to 1.93)

< 0.001

Oceania

5 (3–7)

0.35 (0.22–0.53)

10 (7–15)

0.36 (0.24–0.52)

0.09 (−0.33 to 0.51)

0.6693

Western Sub-Saharan Africa

81 (62–102)

0.25 (0.19–0.32)

272 (201–355)

0.33 (0.24–0.43)

0.88 (0.69 to 1.06)

< 0.001

Eastern Sub-Saharan Africa

157 (106–215)

0.51 (0.34–0.69)

826 (613–1075)

1.05 (0.78–1.37)

2.39 (2.23 to 2.55)

< 0.001