Fig. 2
Histopathological changes of abdominal aorta of rats in each group. (A) The vascular wall structure in the Sham group remains intact. (B) In the Model group, the vessel wall is thinned, with discontinuous, partially lost or fragmented elastic and collagen fibers, and a reduction in smooth muscle cells. (C) In the Topiramate group, the vessel wall is partially thinned, but clear inner and outer elastic layers are still visible, and smooth muscle cells are arranged in an orderly fashion. (D) In the Bicuculline group, the vessel wall is significantly thinned, with degradation of the extracellular matrix, smooth muscle cell loss, and dissection formation. (E) Quantitative analysis of normalized vascular wall thickness. (F) Differences in vascular wall thickness across individual rats.
