Table 1 Clinicopathological parameters according to surgical technique (APR: abdominoperineal resection. LAR*: low anterior and intersphincteric resection, BMI: body mass index, ECOG: Eastern Cooperative Oncology Group, nCRT: neoadjuvant chemoradiotherapy, cT: clinical T level, cN: clinical lymph node status, ypT: post-treatment pathological T level, ypN: post-treatment pathological nodal status, ypM: post-treatment metastasis status, R status: resection status, TRG: tumour regression grading, LN: lymph node, TME quality: quality of total mesorectal excision.
Clinical parameters | APR Group | LAR* Group | p value |
|---|---|---|---|
Age (mean) | 62.1 | 61.9 | 0.5815 |
BMI (mean) | 27.6 | 26.8 | 0.0034 |
ECOG (n = 1161) | 0.1151 | ||
Score > 0 | 71 (24%) | 166 (19%) | |
Score 0 | 228 (76%) | 696 (81%) | |
nCRT (n = 1173) | 0.8462 | ||
5-FU | 152 (50%) | 444 (51%) | |
5-FU + Oxaliplatin | 151 (50%) | 426 (49%) | |
cT (n = 1168) | < 0.00001 | ||
cT2 | 12(4%) | 39 (4%) | |
cT3 | 246 (82%) | 793 (91%) | |
cT4 | 41 (14%) | 37 (4%) | |
cN (n = 1167) | 0.1021 | ||
Negative | 64 (21%) | 229 (26%) | |
Positive | 235 (79%) | 639 (74%) | |
Grade (n = 1100) | |||
G1-G2 | 246 (87%) | 761 (93%) | 0.0038 |
G3-G4 | 36 (13%) | 57 (7%) | |
ypT (n = 1173) | |||
ypT0 | 33 (11%) | 157 (18%) | 0.0054 |
ypT1 | 19 (6%) | 58 (7%) | |
ypT2 | 92 (30%) | 245 (28%) | |
ypT3 | 142 (47%) | 384 (44%) | |
ypT4 | 12 (4%) | 24 (3%) | |
ypTis | 5 (2%) | 2 (0%) | |
ypN (n = 1172) | |||
ypN0 | 197 (65%) | 620 (71%) | 0.0131 |
ypN1 | 69 (23%) | 188 (22%) | |
ypN2 | 37 (12%) | 61 (7%) | |
Number of LNs (mean) | 15.3 | 16.9 | 0.0049 |
R status (n = 1172) | |||
R0 | 281 (93%) | 843 (97%) | 0.0022 |
R > 0 | 22 (7%) | 26 (3%) | |
TRG (n = 1151) | |||
0/1 | 51 (17%) | 146 (17%) | 0.0735 |
2 | 124 (42%) | 336 (39%) | |
3 | 84 (29%) | 217 (25%) | |
4 | 35 (12%) | 158 (18%) | |
TME quality (n = 1127) | |||
Incomplete | 29 (10%) | 21 (3%) | < 0.00001 |
Moderate | 67 (23%) | 96 (11%) | |
Complete | 195 (67%) | 719 (86%) | |
