Table 2 The metabolic traits associated with body mass index, filtered based on the q-values obtained from the IVW method, with the exclusion of metabolic traits exhibiting horizontal pleiotropy.

From: Exploring the causal impact of body mass index on metabolic biomarkers and cholelithiasis risk: a Mendelian randomization analysis

Categories

Serial numbers

Outcome

exposure

Number of SNPs

IVW_Beta

IVW_se

IVW_pval

IVW_q_value

egger_intercept

se

pval

Amino acids

1

Phenylalanine levels || id: ebi-a-GCST90092936

Body mass index || id: ieu-a-835

68

1.16E-01

2.32E-02

6.56E-07

7.10E-06

4.74E-04

1.88E-03

8.02E-01

 

2

Glutamine levels || id: ebi-a-GCST90092818

Body mass index || id: ieu-a-835

67

-1.00E-01

3.30E-02

2.37E-03

4.22E-03

-4.67E-03

2.60E-03

7.67E-02

 

3

Glycine levels || id: ebi-a-GCST90092820

Body mass index || id: ieu-a-835

67

-1.36E-01

2.50E-02

5.35E-08

7.01E-07

-9.96E-04

2.02E-03

6.24E-01

 

4

Isoleucine levels || id: ebi-a-GCST90092843

Body mass index || id: ieu-a-835

68

1.18E-01

2.31E-02

3.18E-07

3.95E-06

8.47E-04

1.87E-03

6.51E-01

 

5

Total concentration of branched-chain amino acids (leucine + isoleucine + valine) || id: ebi-a-GCST90092984

Body mass index || id: ieu-a-835

68

1.50E-01

2.52E-02

2.48E-09

6.69E-08

2.30E-04

2.03E-03

9.10E-01

 

6

Leucine levels || id: ebi-a-GCST90092891

Body mass index || id: ieu-a-835

68

1.25E-01

2.48E-02

4.72E-07

5.60E-06

-1.47E-04

2.01E-03

9.42E-01

 

7

Tyrosine levels || id: ebi-a-GCST90092993

Body mass index || id: ieu-a-835

68

1.53E-01

2.62E-02

5.49E-09

1.05E-07

1.85E-04

2.12E-03

9.30E-01

 

8

Valine levels || id: ebi-a-GCST90092995

Body mass index || id: ieu-a-835

68

1.66E-01

2.60E-02

1.89E-10

2.35E-08

1.58E-04

2.10E-03

9.40E-01

Cholesteryl ester levels

9

Cholesteryl ester levels in HDL || id: ebi-a-GCST90092823

Body mass index || id: ieu-a-835

63

-1.60E-01

3.85E-02

3.06E-05

1.23E-04

-4.32E-03

3.10E-03

1.69E-01

 

10

Cholesteryl ester levels in IDL || id: ebi-a-GCST90092833

Body mass index || id: ieu-a-835

67

-1.14E-01

3.40E-02

7.85E-04

1.69E-03

1.44E-03

2.72E-03

5.99E-01

 

11

Cholesteryl esters to total lipids ratio in IDL || id: ebi-a-GCST90092834

Body mass index || id: ieu-a-835

66

-1.31E-01

3.13E-02

2.79E-05

1.14E-04

1.68E-04

2.52E-03

9.47E-01

 

12

Cholesteryl ester levels in large HDL || id: ebi-a-GCST90092846

Body mass index || id: ieu-a-835

63

-2.22E-01

3.62E-02

9.53E-10

5.03E-08

-1.72E-03

2.88E-03

5.52E-01

 

13

Cholesteryl esters to total lipids ratio in large HDL || id: ebi-a-GCST90092847

Body mass index || id: ieu-a-835

65

-2.00E-01

4.02E-02

6.53E-07

7.10E-06

-5.08E-03

3.14E-03

1.11E-01

 

14

Cholesteryl ester levels in large LDL || id: ebi-a-GCST90092858

Body mass index || id: ieu-a-835

67

-8.00E-02

3.20E-02

1.25E-02

1.92E-02

3.79E-04

2.57E-03

8.83E-01

 

15

Cholesteryl esters to total lipids ratio in large LDL || id: ebi-a-GCST90092859

Body mass index || id: ieu-a-835

68

-8.54E-02

2.94E-02

3.67E-03

6.17E-03

-8.40E-04

2.38E-03

7.25E-01

 

16

Cholesteryl esters to total lipids ratio in large VLDL || id: ebi-a-GCST90092871

Body mass index || id: ieu-a-835

67

-9.80E-02

3.01E-02

1.11E-03

2.19E-03

-3.11E-03

2.38E-03

1.96E-01

 

17

Cholesteryl ester levels in medium HDL || id: ebi-a-GCST90092894

Body mass index || id: ieu-a-835

66

-1.57E-01

3.57E-02

1.13E-05

5.21E-05

-1.65E-03

2.86E-03

5.66E-01

 

18

Cholesteryl esters to total lipids ratio in medium HDL || id: ebi-a-GCST90092895

Body mass index || id: ieu-a-835

67

-1.59E-01

3.71E-02

1.96E-05

8.41E-05

-4.61E-03

2.95E-03

1.24E-01

 

19

Cholesteryl ester levels in medium VLDL || id: ebi-a-GCST90092918

Body mass index || id: ieu-a-835

67

-7.56E-02

2.87E-02

8.33E-03

1.31E-02

3.57E-04

2.30E-03

8.77E-01

 

20

Cholesteryl esters to total lipids ratio in medium VLDL || id: ebi-a-GCST90092919

Body mass index || id: ieu-a-835

67

-1.31E-01

3.55E-02

2.38E-04

6.16E-04

-3.51E-03

2.82E-03

2.17E-01

 

21

Cholesteryl esters to total lipids ratio in small HDL || id: ebi-a-GCST90092947

Body mass index || id: ieu-a-835

68

-6.18E-02

2.73E-02

2.38E-02

3.44E-02

-1.76E-03

2.20E-03

4.27E-01

 

22

Cholesteryl ester levels in very large HDL || id: ebi-a-GCST90093006

Body mass index || id: ieu-a-835

64

-2.25E-01

3.79E-02

2.96E-09

6.69E-08

-2.79E-03

3.00E-03

3.57E-01

 

23

Cholesteryl esters to total lipids ratio in very large HDL || id: ebi-a-GCST90093007

Body mass index || id: ieu-a-835

68

-1.17E-01

3.52E-02

9.10E-04

1.89E-03

-1.95E-04

2.84E-03

9.45E-01

 

24

Cholesteryl ester levels in very large VLDL || id: ebi-a-GCST90093018

Body mass index || id: ieu-a-835

68

7.74E-02

2.84E-02

6.44E-03

1.04E-02

1.77E-03

2.29E-03

4.42E-01

 

25

Cholesteryl esters to total lipids ratio in very large VLDL || id: ebi-a-GCST90093019

Body mass index || id: ieu-a-835

68

-1.36E-01

3.36E-02

5.37E-05

1.91E-04

-3.89E-03

2.67E-03

1.50E-01

 

26

Cholesteryl ester levels in very small VLDL || id: ebi-a-GCST90093030

Body mass index || id: ieu-a-835

67

-8.76E-02

2.91E-02

2.57E-03

4.51E-03

7.65E-04

2.33E-03

7.44E-01

 

27

Cholesteryl esters to total lipids ratio in very small VLDL || id: ebi-a-GCST90093031

Body mass index || id: ieu-a-835

66

-1.63E-01

3.42E-02

1.89E-06

1.43E-05

-3.39E-03

2.72E-03

2.17E-01

 

28

Cholesteryl ester levels in chylomicrons and extremely large VLDL || id: ebi-a-GCST90093042

Body mass index || id: ieu-a-835

67

8.32E-02

2.78E-02

2.79E-03

4.83E-03

3.24E-03

2.22E-03

1.49E-01

 

29

Cholesteryl esters to total lipids ratio in chylomicrons and extremely large VLDL || id: ebi-a-GCST90093043

Body mass index || id: ieu-a-835

68

-8.70E-02

2.48E-02

4.51E-04

1.06E-03

-1.84E-03

1.99E-03

3.59E-01

Free cholesterol levels

30

Free cholesterol levels in HDL || id: ebi-a-GCST90092824

Body mass index || id: ieu-a-835

64

-1.65E-01

3.62E-02

5.13E-06

2.84E-05

-2.03E-03

2.87E-03

4.82E-01

 

31

Free cholesterol levels in IDL || id: ebi-a-GCST90092835

Body mass index || id: ieu-a-835

67

-1.04E-01

3.31E-02

1.66E-03

3.05E-03

2.15E-04

2.65E-03

9.36E-01

 

32

Free cholesterol to total lipids ratio in IDL || id: ebi-a-GCST90092836

Body mass index || id: ieu-a-835

68

-7.94E-02

2.96E-02

7.23E-03

1.15E-02

-4.10E-03

2.34E-03

8.42E-02

 

33

Free cholesterol levels in large HDL || id: ebi-a-GCST90092848

Body mass index || id: ieu-a-835

64

-2.13E-01

3.59E-02

2.76E-09

6.69E-08

-2.20E-03

2.85E-03

4.43E-01

 

34

Free cholesterol to total lipids ratio in large HDL || id: ebi-a-GCST90092849

Body mass index || id: ieu-a-835

67

-1.47E-01

3.87E-02

1.54E-04

4.21E-04

-3.01E-03

3.09E-03

3.33E-01

 

35

Free cholesterol levels in large LDL || id: ebi-a-GCST90092860

Body mass index || id: ieu-a-835

67

-1.09E-01

3.39E-02

1.33E-03

2.57E-03

1.74E-04

2.72E-03

9.49E-01

 

36

Free cholesterol to total lipids ratio in large LDL || id: ebi-a-GCST90092861

Body mass index || id: ieu-a-835

66

-1.53E-01

3.38E-02

6.06E-06

3.28E-05

-4.31E-03

2.66E-03

1.10E-01

 

37

Free cholesterol levels in large VLDL || id: ebi-a-GCST90092872

Body mass index || id: ieu-a-835

68

1.09E-01

2.98E-02

2.53E-04

6.49E-04

2.18E-03

2.39E-03

3.65E-01

 

38

Free cholesterol to total lipids ratio in large VLDL || id: ebi-a-GCST90092873

Body mass index || id: ieu-a-835

68

9.80E-02

2.83E-02

5.27E-04

1.19E-03

-3.55E-04

2.28E-03

8.77E-01

 

39

Free cholesterol levels in LDL || id: ebi-a-GCST90092885

Body mass index || id: ieu-a-835

67

-9.04E-02

3.29E-02

6.01E-03

9.84E-03

1.91E-04

2.64E-03

9.43E-01

 

40

Free cholesterol levels in medium HDL || id: ebi-a-GCST90092896

Body mass index || id: ieu-a-835

66

-1.56E-01

3.52E-02

9.46E-06

4.71E-05

-1.61E-03

2.82E-03

5.70E-01

 

41

Free cholesterol to total lipids ratio in medium HDL || id: ebi-a-GCST90092897

Body mass index || id: ieu-a-835

64

-1.65E-01

3.84E-02

1.77E-05

7.72E-05

-2.55E-03

3.04E-03

4.04E-01

 

42

Free cholesterol to total lipids ratio in medium LDL || id: ebi-a-GCST90092909

Body mass index || id: ieu-a-835

67

-1.34E-01

3.51E-02

1.33E-04

3.78E-04

-3.88E-03

2.80E-03

1.70E-01

 

43

Free cholesterol to total lipids ratio in medium VLDL || id: ebi-a-GCST90092921

Body mass index || id: ieu-a-835

67

-1.14E-01

3.36E-02

6.84E-04

1.49E-03

-3.20E-03

2.67E-03

2.35E-01

 

44

Free cholesterol levels in small HDL || id: ebi-a-GCST90092948

Body mass index || id: ieu-a-835

67

-8.02E-02

3.28E-02

1.44E-02

2.17E-02

1.87E-03

2.62E-03

4.79E-01

 

45

Free cholesterol to total lipids ratio in small HDL || id: ebi-a-GCST90092949

Body mass index || id: ieu-a-835

67

-1.50E-01

3.88E-02

1.15E-04

3.42E-04

-3.32E-03

3.09E-03

2.86E-01

 

46

Free cholesterol to total lipids ratio in small LDL || id: ebi-a-GCST90092961

Body mass index || id: ieu-a-835

68

-1.13E-01

3.32E-02

6.30E-04

1.40E-03

-3.26E-03

2.65E-03

2.23E-01

 

47

Free cholesterol to total lipids ratio in small VLDL || id: ebi-a-GCST90092973

Body mass index || id: ieu-a-835

66

-1.50E-01

3.19E-02

2.60E-06

1.75E-05

-1.84E-03

2.54E-03

4.70E-01

 

48

Total free cholesterol levels || id: ebi-a-GCST90092988

Body mass index || id: ieu-a-835

67

-1.03E-01

3.25E-02

1.49E-03

2.77E-03

5.79E-04

2.61E-03

8.25E-01

 

49

Free cholesterol levels in very large HDL || id: ebi-a-GCST90093008

Body mass index || id: ieu-a-835

66

-1.70E-01

3.82E-02

8.32E-06

4.32E-05

-4.04E-03

3.03E-03

1.88E-01

 

50

Free cholesterol to total lipids ratio in very large HDL || id: ebi-a-GCST90093009

Body mass index || id: ieu-a-835

64

2.18E-01

3.27E-02

2.46E-11

6.13E-09

2.87E-03

2.58E-03

2.71E-01

 

51

Free cholesterol levels in very large VLDL || id: ebi-a-GCST90093020

Body mass index || id: ieu-a-835

68

1.08E-01

2.95E-02

2.34E-04

6.16E-04

2.12E-03

2.37E-03

3.73E-01

 

52

Free cholesterol to total lipids ratio in very large VLDL || id: ebi-a-GCST90093021

Body mass index || id: ieu-a-835

67

-9.08E-02

2.85E-02

1.45E-03

2.72E-03

-4.00E-03

2.23E-03

7.79E-02

 

53

Free cholesterol to total lipids ratio in very small VLDL || id: ebi-a-GCST90093033

Body mass index || id: ieu-a-835

67

-7.22E-02

2.65E-02

6.51E-03

1.05E-02

-2.68E-03

2.10E-03

2.08E-01

 

54

Free cholesterol levels in chylomicrons and extremely large VLDL || id: ebi-a-GCST90093044

Body mass index || id: ieu-a-835

68

1.21E-01

3.05E-02

7.58E-05

2.52E-04

2.60E-03

2.44E-03

2.91E-01

 

55

Free cholesterol to total lipids ratio in chylomicrons and extremely large VLDL || id: ebi-a-GCST90093045

Body mass index || id: ieu-a-835

68

-6.19E-02

2.23E-02

5.46E-03

9.00E-03

-1.13E-03

1.80E-03

5.32E-01

Cholesterol levels

56

Clinical LDL cholesterol levels || id: ebi-a-GCST90092814

Body mass index || id: ieu-a-835

67

-6.79E-02

3.05E-02

2.60E-02

3.72E-02

6.12E-04

2.45E-03

8.03E-01

 

57

HDL cholesterol levels || id: ebi-a-GCST90092822

Body mass index || id: ieu-a-835

64

-1.76E-01

3.77E-02

3.01E-06

1.92E-05

-2.11E-03

2.99E-03

4.84E-01

 

58

Cholesterol levels in IDL || id: ebi-a-GCST90092831

Body mass index || id: ieu-a-835

67

-1.12E-01

3.38E-02

9.20E-04

1.89E-03

1.13E-03

2.71E-03

6.78E-01

 

59

Cholesterol to total lipids ratio in IDL || id: ebi-a-GCST90092832

Body mass index || id: ieu-a-835

66

-1.30E-01

3.24E-02

5.78E-05

2.00E-04

-1.97E-03

2.59E-03

4.50E-01

 

60

Cholesterol levels in large HDL || id: ebi-a-GCST90092844

Body mass index || id: ieu-a-835

63

-2.19E-01

3.60E-02

1.24E-09

5.14E-08

-1.72E-03

2.86E-03

5.50E-01

 

61

Cholesterol to total lipids ratio in large HDL || id: ebi-a-GCST90092845

Body mass index || id: ieu-a-835

65

-1.96E-01

4.14E-02

2.13E-06

1.52E-05

-5.22E-03

3.24E-03

1.12E-01

 

62

Cholesterol levels in large LDL || id: ebi-a-GCST90092856

Body mass index || id: ieu-a-835

67

-8.86E-02

3.26E-02

6.57E-03

1.05E-02

3.17E-04

2.62E-03

9.04E-01

 

63

Cholesterol to total lipids ratio in large LDL || id: ebi-a-GCST90092857

Body mass index || id: ieu-a-835

66

-1.71E-01

3.69E-02

3.46E-06

2.10E-05

-3.28E-03

2.94E-03

2.69E-01

 

64

Cholesterol levels in large VLDL || id: ebi-a-GCST90092868

Body mass index || id: ieu-a-835

68

8.46E-02

2.86E-02

3.12E-03

5.33E-03

1.94E-03

2.30E-03

4.02E-01

 

65

LDL cholesterol levels || id: ebi-a-GCST90092883

Body mass index || id: ieu-a-835

67

-6.55E-02

3.07E-02

3.28E-02

4.64E-02

4.06E-04

2.46E-03

8.70E-01

 

66

Cholesterol levels in medium HDL || id: ebi-a-GCST90092892

Body mass index || id: ieu-a-835

66

-1.58E-01

3.57E-02

1.02E-05

4.97E-05

-1.65E-03

2.86E-03

5.67E-01

 

67

Cholesterol to total lipids ratio in medium HDL || id: ebi-a-GCST90092893

Body mass index || id: ieu-a-835

66

-1.73E-01

4.02E-02

1.72E-05

7.67E-05

-4.67E-03

3.18E-03

1.47E-01

 

68

Cholesterol to total lipids ratio in medium LDL || id: ebi-a-GCST90092905

Body mass index || id: ieu-a-835

66

-1.45E-01

2.57E-02

1.80E-08

2.64E-07

-2.64E-03

2.04E-03

2.01E-01

 

69

Cholesterol to total lipids ratio in medium VLDL || id: ebi-a-GCST90092917

Body mass index || id: ieu-a-835

67

-1.27E-01

3.52E-02

3.16E-04

7.87E-04

-3.49E-03

2.79E-03

2.15E-01

 

70

Cholesterol to total lipids ratio in small HDL || id: ebi-a-GCST90092945

Body mass index || id: ieu-a-835

68

-1.05E-01

3.31E-02

1.42E-03

2.69E-03

-2.89E-03

2.65E-03

2.80E-01

 

71

Cholesterol to total lipids ratio in small LDL || id: ebi-a-GCST90092957

Body mass index || id: ieu-a-835

68

-1.24E-01

2.56E-02

1.33E-06

1.15E-05

-4.10E-04

2.07E-03

8.43E-01

 

72

Cholesterol to total lipids ratio in small VLDL || id: ebi-a-GCST90092969

Body mass index || id: ieu-a-835

67

-7.77E-02

3.04E-02

1.07E-02

1.66E-02

-2.27E-03

2.43E-03

3.53E-01

 

73

Total cholesterol levels || id: ebi-a-GCST90092985

Body mass index || id: ieu-a-835

66

-1.13E-01

3.37E-02

8.26E-04

1.74E-03

8.02E-04

2.68E-03

7.66E-01

 

74

Total esterified cholesterol levels || id: ebi-a-GCST90092986

Body mass index || id: ieu-a-835

65

-1.08E-01

3.32E-02

1.16E-03

2.27E-03

-3.31E-04

2.64E-03

9.01E-01

 

75

Cholesterol levels in very large HDL || id: ebi-a-GCST90093004

Body mass index || id: ieu-a-835

65

-1.95E-01

4.06E-02

1.59E-06

1.32E-05

-4.48E-03

3.19E-03

1.65E-01

 

76

Cholesterol to total lipids ratio in very large HDL || id: ebi-a-GCST90093005

Body mass index || id: ieu-a-835

68

9.48E-02

2.76E-02

6.02E-04

1.35E-03

2.38E-03

2.21E-03

2.87E-01

 

77

Cholesterol levels in very large VLDL || id: ebi-a-GCST90093016

Body mass index || id: ieu-a-835

68

9.43E-02

2.89E-02

1.11E-03

2.19E-03

1.91E-03

2.33E-03

4.16E-01

 

78

Cholesterol to total lipids ratio in very large VLDL || id: ebi-a-GCST90093017

Body mass index || id: ieu-a-835

67

-1.23E-01

3.20E-02

1.25E-04

3.63E-04

-3.86E-03

2.52E-03

1.30E-01

 

79

Cholesterol levels in very small VLDL || id: ebi-a-GCST90093028

Body mass index || id: ieu-a-835

67

-6.97E-02

2.79E-02

1.24E-02

1.91E-02

7.51E-04

2.24E-03

7.38E-01

 

80

Cholesterol to total lipids ratio in very small VLDL || id: ebi-a-GCST90093029

Body mass index || id: ieu-a-835

66

-1.55E-01

3.38E-02

4.41E-06

2.50E-05

-3.49E-03

2.69E-03

1.98E-01

 

81

Cholesterol levels in chylomicrons and extremely large VLDL || id: ebi-a-GCST90093040

Body mass index || id: ieu-a-835

68

1.09E-01

3.03E-02

3.20E-04

7.89E-04

2.39E-03

2.43E-03

3.29E-01

 

82

Cholesterol to total lipids ratio in chylomicrons and extremely large VLDL || id: ebi-a-GCST90093041

Body mass index || id: ieu-a-835

68

-8.50E-02

2.36E-02

3.13E-04

7.87E-04

-1.21E-03

1.90E-03

5.26E-01

Particle concentrations or sizes

83

Concentration of HDL particles || id: ebi-a-GCST90092826

Body mass index || id: ieu-a-835

66

-1.46E-01

3.54E-02

3.96E-05

1.49E-04

-1.02E-03

2.84E-03

7.21E-01

 

84

Concentration of large HDL particles || id: ebi-a-GCST90092851

Body mass index || id: ieu-a-835

63

-2.17E-01

3.52E-02

7.11E-10

5.03E-08

-1.68E-03

2.79E-03

5.49E-01

 

85

Concentration of large VLDL particles || id: ebi-a-GCST90092875

Body mass index || id: ieu-a-835

68

1.05E-01

2.95E-02

3.56E-04

8.69E-04

2.25E-03

2.37E-03

3.47E-01

 

86

Concentration of medium HDL particles || id: ebi-a-GCST90092899

Body mass index || id: ieu-a-835

66

-1.47E-01

3.35E-02

1.11E-05

5.21E-05

-1.32E-03

2.69E-03

6.26E-01

 

87

Concentration of small VLDL particles || id: ebi-a-GCST90092975

Body mass index || id: ieu-a-835

68

6.19E-02

2.75E-02

2.45E-02

3.52E-02

1.44E-03

2.22E-03

5.19E-01

 

88

Total concentration of lipoprotein particles || id: ebi-a-GCST90092990

Body mass index || id: ieu-a-835

66

-1.45E-01

3.59E-02

5.27E-05

1.91E-04

-8.56E-04

2.88E-03

7.68E-01

 

89

Concentration of very large HDL particles || id: ebi-a-GCST90093011

Body mass index || id: ieu-a-835

65

-1.94E-01

3.98E-02

1.10E-06

1.01E-05

-4.67E-03

3.12E-03

1.39E-01

 

90

Concentration of very large VLDL particles || id: ebi-a-GCST90093023

Body mass index || id: ieu-a-835

68

1.22E-01

3.08E-02

7.74E-05

2.54E-04

2.45E-03

2.48E-03

3.26E-01

 

91

Concentration of chylomicrons and extremely large VLDL particles || id: ebi-a-GCST90093047

Body mass index || id: ieu-a-835

68

1.26E-01

3.07E-02

3.82E-05

1.46E-04

2.45E-03

2.46E-03

3.24E-01

 

92

Average diameter for HDL particles || id: ebi-a-GCST90092828

Body mass index || id: ieu-a-835

65

-1.83E-01

3.78E-02

1.28E-06

1.13E-05

-4.09E-03

2.97E-03

1.73E-01

 

93

Average diameter for LDL particles || id: ebi-a-GCST90092889

Body mass index || id: ieu-a-835

68

-8.60E-02

3.36E-02

1.05E-02

1.64E-02

1.75E-03

2.71E-03

5.19E-01

 

94

Average diameter for VLDL particles || id: ebi-a-GCST90093002

Body mass index || id: ieu-a-835

68

1.32E-01

3.11E-02

2.23E-05

9.42E-05

2.16E-03

2.50E-03

3.90E-01

Triglyceride levels

95

Triglyceride levels in IDL || id: ebi-a-GCST90092841

Body mass index || id: ieu-a-835

68

7.71E-02

2.64E-02

3.51E-03

5.94E-03

1.71E-03

2.12E-03

4.23E-01

 

96

Triglycerides to total lipids ratio in IDL || id: ebi-a-GCST90092842

Body mass index || id: ieu-a-835

66

1.47E-01

3.34E-02

1.11E-05

5.21E-05

3.10E-03

2.66E-03

2.48E-01

 

97

Triglyceride levels in large HDL || id: ebi-a-GCST90092854

Body mass index || id: ieu-a-835

68

-9.15E-02

2.45E-02

1.91E-04

5.11E-04

4.37E-04

1.98E-03

8.26E-01

 

98

Triglycerides to total lipids ratio in large HDL || id: ebi-a-GCST90092855

Body mass index || id: ieu-a-835

67

1.54E-01

3.95E-02

9.41E-05

3.00E-04

4.32E-03

3.16E-03

1.76E-01

 

99

Triglyceride levels in large LDL || id: ebi-a-GCST90092866

Body mass index || id: ieu-a-835

68

7.86E-02

2.60E-02

2.53E-03

4.46E-03

1.30E-03

2.10E-03

5.38E-01

 

100

Triglycerides to total lipids ratio in large LDL || id: ebi-a-GCST90092867

Body mass index || id: ieu-a-835

66

1.46E-01

3.18E-02

4.43E-06

2.50E-05

2.97E-03

2.53E-03

2.45E-01

 

101

Triglyceride levels in large VLDL || id: ebi-a-GCST90092878

Body mass index || id: ieu-a-835

68

9.53E-02

2.91E-02

1.07E-03

2.15E-03

2.54E-03

2.34E-03

2.81E-01

 

102

Triglyceride levels in LDL || id: ebi-a-GCST90092890

Body mass index || id: ieu-a-835

68

8.51E-02

2.66E-02

1.37E-03

2.63E-03

1.41E-03

2.14E-03

5.13E-01

 

103

Triglycerides to total lipids ratio in medium HDL || id: ebi-a-GCST90092903

Body mass index || id: ieu-a-835

67

1.39E-01

3.73E-02

1.89E-04

5.11E-04

4.12E-03

2.98E-03

1.72E-01

 

104

Triglyceride levels in medium LDL || id: ebi-a-GCST90092914

Body mass index || id: ieu-a-835

68

9.00E-02

2.70E-02

8.73E-04

1.83E-03

1.36E-03

2.18E-03

5.36E-01

 

105

Triglycerides to total lipids ratio in medium LDL || id: ebi-a-GCST90092915

Body mass index || id: ieu-a-835

66

1.11E-01

2.91E-02

1.35E-04

3.78E-04

2.44E-03

2.32E-03

2.97E-01

 

106

Triglyceride levels in medium VLDL || id: ebi-a-GCST90092926

Body mass index || id: ieu-a-835

68

7.70E-02

2.82E-02

6.32E-03

1.03E-02

2.35E-03

2.26E-03

3.02E-01

 

107

Triglycerides to total lipids ratio in medium VLDL || id: ebi-a-GCST90092927

Body mass index || id: ieu-a-835

67

1.21E-01

3.46E-02

4.41E-04

1.05E-03

3.28E-03

2.74E-03

2.36E-01

 

108

Triglyceride levels in small HDL || id: ebi-a-GCST90092954

Body mass index || id: ieu-a-835

68

1.32E-01

3.41E-02

1.03E-04

3.16E-04

3.19E-03

2.73E-03

2.47E-01

 

109

Triglycerides to total lipids ratio in small HDL || id: ebi-a-GCST90092955

Body mass index || id: ieu-a-835

67

1.52E-01

3.62E-02

2.61E-05

1.08E-04

3.85E-03

2.89E-03

1.89E-01

 

110

Triglyceride levels in small LDL || id: ebi-a-GCST90092966

Body mass index || id: ieu-a-835

68

9.36E-02

2.79E-02

8.07E-04

1.72E-03

1.92E-03

2.25E-03

3.96E-01

 

111

Triglycerides to total lipids ratio in small LDL || id: ebi-a-GCST90092967

Body mass index || id: ieu-a-835

66

1.36E-01

2.91E-02

3.21E-06

2.00E-05

1.56E-03

2.31E-03

5.02E-01

 

112

Triglyceride levels in small VLDL || id: ebi-a-GCST90092978

Body mass index || id: ieu-a-835

68

9.57E-02

2.96E-02

1.25E-03

2.42E-03

2.55E-03

2.38E-03

2.86E-01

 

113

Triglycerides to total lipids ratio in small VLDL || id: ebi-a-GCST90092979

Body mass index || id: ieu-a-835

67

9.17E-02

3.16E-02

3.74E-03

6.26E-03

2.43E-03

2.52E-03

3.39E-01

 

114

Ratio of triglycerides to phosphoglycerides || id: ebi-a-GCST90092983

Body mass index || id: ieu-a-835

67

1.58E-01

3.38E-02

2.88E-06

1.89E-05

3.89E-03

2.70E-03

1.54E-01

 

115

Total triglycerides levels || id: ebi-a-GCST90092992

Body mass index || id: ieu-a-835

68

1.02E-01

2.93E-02

5.16E-04

1.18E-03

2.67E-03

2.34E-03

2.59E-01

 

116

Triglyceride levels in VLDL || id: ebi-a-GCST90093003

Body mass index || id: ieu-a-835

68

1.05E-01

2.97E-02

3.86E-04

9.24E-04

2.67E-03

2.38E-03

2.65E-01

 

117

Triglycerides to total lipids ratio in very large HDL || id: ebi-a-GCST90093015

Body mass index || id: ieu-a-835

67

1.59E-01

3.52E-02

6.40E-06

3.39E-05

4.74E-03

2.79E-03

9.45E-02

 

118

Triglyceride levels in very large VLDL || id: ebi-a-GCST90093026

Body mass index || id: ieu-a-835

68

1.24E-01

3.16E-02

8.77E-05

2.84E-04

2.90E-03

2.53E-03

2.56E-01

 

119

Triglycerides to total lipids ratio in very large VLDL || id: ebi-a-GCST90093027

Body mass index || id: ieu-a-835

67

9.83E-02

2.98E-02

9.74E-04

1.98E-03

4.00E-03

2.34E-03

9.24E-02

 

120

Triglyceride levels in very small VLDL || id: ebi-a-GCST90093038

Body mass index || id: ieu-a-835

68

9.71E-02

2.86E-02

6.72E-04

1.48E-03

2.19E-03

2.29E-03

3.43E-01

 

121

Triglycerides to total lipids ratio in very small VLDL || id: ebi-a-GCST90093039

Body mass index || id: ieu-a-835

66

1.33E-01

3.31E-02

5.58E-05

1.96E-04

3.19E-03

2.63E-03

2.30E-01

 

122

Triglyceride levels in chylomicrons and extremely large VLDL || id: ebi-a-GCST90093050

Body mass index || id: ieu-a-835

68

1.18E-01

2.92E-02

5.32E-05

1.91E-04

2.52E-03

2.34E-03

2.85E-01

Phospholipid levels

123

Total cholines levels || id: ebi-a-GCST90092812

Body mass index || id: ieu-a-835

65

-1.14E-01

3.11E-02

2.56E-04

6.49E-04

3.94E-05

2.48E-03

9.87E-01

 

124

Phosphatidylcholine levels || id: ebi-a-GCST90092937

Body mass index || id: ieu-a-835

65

-1.22E-01

3.06E-02

7.07E-05

2.41E-04

-7.00E-05

2.44E-03

9.77E-01

 

125

Phosphoglycerides levels || id: ebi-a-GCST90092938

Body mass index || id: ieu-a-835

65

-9.48E-02

2.97E-02

1.40E-03

2.66E-03

4.37E-04

2.37E-03

8.54E-01

 

126

Sphingomyelin levels || id: ebi-a-GCST90092982

Body mass index || id: ieu-a-835

65

-1.13E-01

3.42E-02

9.76E-04

1.98E-03

-3.56E-04

2.73E-03

8.97E-01

 

127

Phospholipid levels in HDL || id: ebi-a-GCST90092827

Body mass index || id: ieu-a-835

66

-1.50E-01

3.39E-02

9.07E-06

4.61E-05

-1.64E-03

2.72E-03

5.48E-01

 

128

Phospholipid levels in IDL || id: ebi-a-GCST90092839

Body mass index || id: ieu-a-835

67

-9.77E-02

3.20E-02

2.28E-03

4.11E-03

5.36E-04

2.57E-03

8.35E-01

 

129

Phospholipid levels in large HDL || id: ebi-a-GCST90092852

Body mass index || id: ieu-a-835

64

-1.96E-01

3.41E-02

8.75E-09

1.56E-07

-1.57E-03

2.71E-03

5.65E-01

 

130

Phospholipids to total lipids ratio in large HDL || id: ebi-a-GCST90092853

Body mass index || id: ieu-a-835

66

2.29E-01

3.83E-02

2.20E-09

6.69E-08

4.76E-03

2.99E-03

1.17E-01

 

131

Phospholipid levels in large LDL || id: ebi-a-GCST90092864

Body mass index || id: ieu-a-835

67

-7.28E-02

3.07E-02

1.78E-02

2.61E-02

7.67E-04

2.46E-03

7.57E-01

 

132

Phospholipid levels in large VLDL || id: ebi-a-GCST90092876

Body mass index || id: ieu-a-835

68

1.13E-01

3.07E-02

2.35E-04

6.16E-04

2.37E-03

2.46E-03

3.38E-01

 

133

Phospholipids to total lipids ratio in large VLDL || id: ebi-a-GCST90092877

Body mass index || id: ieu-a-835

67

1.29E-01

3.36E-02

1.25E-04

3.63E-04

3.62E-03

2.68E-03

1.81E-01

 

134

Phospholipid levels in medium HDL || id: ebi-a-GCST90092900

Body mass index || id: ieu-a-835

66

-1.09E-01

3.05E-02

3.63E-04

8.76E-04

-1.60E-04

2.45E-03

9.48E-01

 

135

Phospholipids to total lipids ratio in medium HDL || id: ebi-a-GCST90092901

Body mass index || id: ieu-a-835

65

2.04E-01

4.17E-02

1.02E-06

1.01E-05

4.92E-03

3.27E-03

1.38E-01

 

136

Phospholipids to total lipids ratio in medium LDL || id: ebi-a-GCST90092913

Body mass index || id: ieu-a-835

68

5.74E-02

2.37E-02

1.52E-02

2.27E-02

2.21E-03

1.89E-03

2.47E-01

 

137

Phospholipids to total lipids ratio in medium VLDL || id: ebi-a-GCST90092925

Body mass index || id: ieu-a-835

67

-9.61E-02

3.15E-02

2.29E-03

4.11E-03

-2.31E-03

2.51E-03

3.62E-01

 

138

Phospholipids to total lipids ratio in small VLDL || id: ebi-a-GCST90092977

Body mass index || id: ieu-a-835

66

-1.39E-01

3.18E-02

1.19E-05

5.39E-05

-1.80E-03

2.52E-03

4.79E-01

 

139

Total phospholipid levels in lipoprotein particles || id: ebi-a-GCST90092991

Body mass index || id: ieu-a-835

65

-9.36E-02

3.04E-02

2.06E-03

3.77E-03

2.24E-04

2.42E-03

9.26E-01

 

140

Phospholipid levels in VLDL || id: ebi-a-GCST90093001

Body mass index || id: ieu-a-835

68

6.56E-02

2.74E-02

1.69E-02

2.49E-02

1.57E-03

2.21E-03

4.80E-01

 

141

Phospholipid levels in very large HDL || id: ebi-a-GCST90093012

Body mass index || id: ieu-a-835

65

-1.81E-01

3.82E-02

2.05E-06

1.50E-05

-4.41E-03

2.99E-03

1.46E-01

 

142

Phospholipids to total lipids ratio in very large HDL || id: ebi-a-GCST90093013

Body mass index || id: ieu-a-835

67

-1.60E-01

3.35E-02

1.65E-06

1.33E-05

-4.06E-03

2.66E-03

1.32E-01

 

143

Phospholipid levels in very large VLDL || id: ebi-a-GCST90093024

Body mass index || id: ieu-a-835

68

1.17E-01

3.03E-02

1.12E-04

3.36E-04

2.28E-03

2.43E-03

3.52E-01

 

144

Phospholipids to total lipids ratio in very small VLDL || id: ebi-a-GCST90093037

Body mass index || id: ieu-a-835

66

1.86E-01

3.16E-02

4.11E-09

8.52E-08

3.11E-03

2.51E-03

2.19E-01

 

145

Phospholipid levels in chylomicrons and extremely large VLDL || id: ebi-a-GCST90093048

Body mass index || id: ieu-a-835

68

1.28E-01

3.10E-02

3.60E-05

1.41E-04

2.91E-03

2.48E-03

2.45E-01

 

146

Phospholipids to total lipids ratio in chylomicrons and extremely large VLDL || id: ebi-a-GCST90093049

Body mass index || id: ieu-a-835

68

1.07E-01

3.06E-02

4.79E-04

1.12E-03

1.22E-03

2.47E-03

6.24E-01

Total lipid levels

147

Total lipid levels in HDL || id: ebi-a-GCST90092825

Body mass index || id: ieu-a-835

66

-1.71E-01

3.62E-02

2.20E-06

1.52E-05

-2.20E-03

2.90E-03

4.50E-01

 

148

Total lipid levels in IDL || id: ebi-a-GCST90092837

Body mass index || id: ieu-a-835

67

-9.99E-02

3.25E-02

2.14E-03

3.90E-03

1.02E-03

2.61E-03

6.98E-01

 

149

Total lipid levels in large HDL || id: ebi-a-GCST90092850

Body mass index || id: ieu-a-835

64

-2.12E-01

3.54E-02

2.04E-09

6.69E-08

-1.92E-03

2.82E-03

4.97E-01

 

150

Total lipid levels in large LDL || id: ebi-a-GCST90092862

Body mass index || id: ieu-a-835

67

-7.75E-02

3.17E-02

1.45E-02

2.17E-02

4.48E-04

2.54E-03

8.61E-01

 

151

Total lipid levels in large VLDL || id: ebi-a-GCST90092874

Body mass index || id: ieu-a-835

68

9.93E-02

2.93E-02

7.11E-04

1.54E-03

2.36E-03

2.35E-03

3.20E-01

 

152

Total lipid levels in medium HDL || id: ebi-a-GCST90092898

Body mass index || id: ieu-a-835

66

-1.30E-01

3.23E-02

5.31E-05

1.91E-04

-7.30E-04

2.59E-03

7.79E-01

 

153

Total lipid levels in lipoprotein particles || id: ebi-a-GCST90092989

Body mass index || id: ieu-a-835

67

-7.38E-02

3.07E-02

1.63E-02

2.42E-02

1.01E-03

2.46E-03

6.84E-01

 

154

Total lipid levels in VLDL || id: ebi-a-GCST90092999

Body mass index || id: ieu-a-835

68

7.82E-02

2.77E-02

4.74E-03

7.87E-03

1.83E-03

2.23E-03

4.15E-01

 

155

Total lipid levels in very large HDL || id: ebi-a-GCST90093010

Body mass index || id: ieu-a-835

65

-1.88E-01

3.93E-02

1.83E-06

1.42E-05

-4.51E-03

3.08E-03

1.49E-01

 

156

Total lipid levels in very large VLDL || id: ebi-a-GCST90093022

Body mass index || id: ieu-a-835

68

1.19E-01

3.06E-02

9.80E-05

3.05E-04

2.50E-03

2.46E-03

3.13E-01

 

157

Total lipid levels in chylomicrons and extremely large VLDL || id: ebi-a-GCST90093046

Body mass index || id: ieu-a-835

68

1.18E-01

3.03E-02

9.52E-05

3.00E-04

2.56E-03

2.43E-03

2.96E-01

Fatty acid levels

158

Ratio of docosahexaenoic acid to total fatty acid levels || id: ebi-a-GCST90092817

Body mass index || id: ieu-a-835

68

-1.10E-01

2.66E-02

3.62E-05

1.41E-04

1.04E-04

2.15E-03

9.61E-01

 

159

Ratio of linoleic acid to total fatty acids || id: ebi-a-GCST90092881

Body mass index || id: ieu-a-835

67

-1.66E-01

3.04E-02

4.67E-08

6.46E-07

-4.12E-03

2.38E-03

8.87E-02

 

160

Monounsaturated fatty acid levels || id: ebi-a-GCST90092928

Body mass index || id: ieu-a-835

68

7.86E-02

2.61E-02

2.60E-03

4.53E-03

2.61E-03

2.09E-03

2.16E-01

 

161

Ratio of monounsaturated fatty acids to total fatty acids || id: ebi-a-GCST90092929

Body mass index || id: ieu-a-835

67

1.87E-01

3.06E-02

1.01E-09

5.03E-08

4.39E-03

2.42E-03

7.36E-02

 

162

Omega-6 fatty acid levels || id: ebi-a-GCST90092933

Body mass index || id: ieu-a-835

66

-6.60E-02

2.80E-02

1.84E-02

2.68E-02

1.17E-03

2.23E-03

6.02E-01

 

163

Ratio of omega-6 fatty acids to total fatty acids || id: ebi-a-GCST90092935

Body mass index || id: ieu-a-835

68

-1.44E-01

2.95E-02

1.09E-06

1.01E-05

-3.48E-03

2.35E-03

1.43E-01

 

164

Polyunsaturated fatty acid levels || id: ebi-a-GCST90092939

Body mass index || id: ieu-a-835

67

-7.33E-02

2.99E-02

1.42E-02

2.16E-02

1.22E-03

2.40E-03

6.14E-01

 

165

Ratio of polyunsaturated fatty acids to monounsaturated fatty acids || id: ebi-a-GCST90092940

Body mass index || id: ieu-a-835

68

-1.79E-01

3.15E-02

1.23E-08

1.91E-07

-3.34E-03

2.51E-03

1.89E-01

 

166

Ratio of polyunsaturated fatty acids to total fatty acids || id: ebi-a-GCST90092941

Body mass index || id: ieu-a-835

68

-1.44E-01

2.95E-02

1.08E-06

1.01E-05

-3.17E-03

2.35E-03

1.82E-01

 

167

Docosahexaenoic acid levels || id: ebi-a-GCST90092816

Body mass index || id: ieu-a-835

68

-1.13E-01

2.91E-02

1.10E-04

3.34E-04

1.29E-03

2.35E-03

5.84E-01

 

168

Linoleic acid levels || id: ebi-a-GCST90092880

Body mass index || id: ieu-a-835

66

-7.86E-02

2.64E-02

2.91E-03

4.99E-03

-1.70E-05

2.10E-03

9.94E-01

 

169

Degree of unsaturation || id: ebi-a-GCST90092994

Body mass index || id: ieu-a-835

68

-1.16E-01

2.92E-02

7.23E-05

2.43E-04

-5.31E-04

2.36E-03

8.23E-01

Other metabolites

170

Acetoacetate levels || id: ebi-a-GCST90092804

Body mass index || id: ieu-a-835

68

9.26E-02

2.65E-02

4.86E-04

1.12E-03

2.96E-04

2.15E-03

8.91E-01

 

171

Albumin levels || id: ebi-a-GCST90092807

Body mass index || id: ieu-a-835

68

-1.07E-01

2.79E-02

1.34E-04

3.78E-04

1.19E-03

2.25E-03

5.99E-01

 

172

Apolipoprotein A1 levels || id: ebi-a-GCST90092808

Body mass index || id: ieu-a-835

66

-1.61E-01

3.48E-02

3.86E-06

2.29E-05

-1.68E-03

2.79E-03

5.49E-01

 

173

Ratio of apolipoprotein B to apolipoprotein A1 levels || id: ebi-a-GCST90092810

Body mass index || id: ieu-a-835

68

8.07E-02

3.22E-02

1.21E-02

1.88E-02

1.31E-04

2.60E-03

9.60E-01

 

174

Glucose levels || id: ebi-a-GCST90092819

Body mass index || id: ieu-a-835

67

9.40E-02

2.48E-02

1.53E-04

4.21E-04

-1.74E-03

1.99E-03

3.86E-01

 

175

Glycoprotein acetyls levels || id: ebi-a-GCST90092821

Body mass index || id: ieu-a-835

68

1.66E-01

2.91E-02

1.11E-08

1.85E-07

3.49E-03

2.31E-03

1.37E-01

 

176

3-Hydroxybutyrate levels || id: ebi-a-GCST90092811

Body mass index || id: ieu-a-835

68

6.48E-02

2.98E-02

3.00E-02

4.26E-02

-8.03E-04

2.41E-03

7.40E-01

  1. We identified metabolic traits associated with body mass index, filtered them based on the q-values obtained from the IVW method, and excluded those metabolic traits exhibiting horizontal pleiotropy. The IVW method, known for its heightened sensitivity in detecting causality, serves as our primary tool to ascertain the presence of a causal relationship. The MR-Egger method is also employed for detecting horizontal pleiotropy due to its allowance for the presence of non-zero intercepts (The columns in the table corresponding to “egger_intercept”, “se”, and “pval”), a p_value below 0.05 suggests the existence of horizontal pleiotropy. IVW: Inverse Variance Weighted method; MR_Egger: MR-Egger method; SNPs: Single-nucleotide polymorphisms; q_value: The P value post FDR method (Benjamini and Hochberg) corrected; pval: p-value.