Fig. 7
From: FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region
EDB(−)FN1 impairs tumor growth while EDB(+)FN1 promotes LNM in mice models. (A) Tumor formation by shFN1 or shEDB cells injected into the subcutaneous tissue of nude mice, and tumor growth curves are shown. (B) The expression of p53 and p21 in subcutaneous tumor tissues were evaluated by IHC. Scale bars: 50 μm. (C) Representative images of popliteal lymph node (LN) metastasis model of nude mouse, the indicated K1 cells were injected into the footpads, and images of popliteal LNs and histogram analysis of the LN volume in the indicated cells (n = 3). (D) The image of LYVE-1 expression in popliteal LNs tested by IHC. (E) The expression of VEGFC and CK7 in popliteal LNs of indicated groups. Scale bars: 50 μm.
