Fig. 8
From: FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region
The expression of EDB(−)FN1, EDB(+)FN1 and ZMAT3 in PTC patients. (A) The percentage of EDB(−)FN1 and EDB(+)FN1 accounting for FN1 in tumors with-LNM (N1) and without-LNM (N0) respectively in TCGA dataset from the TSVdb database. (B) The ratio of EDB(−)FN1 and EDB(+)FN1 in different tumor size stage (T1–T4) in TCGA dataset from the TSVdb database. (C) Representative images of EDB region expression in PTC tumors with-LNM (N1) and without-LNM (N0), and statistical diagram was shown. Scale bars: 50 μm. (D) Diagnostic efficacy of EDB region expression in PTC with LNM evaluated by ROC curve. (E) The differential expression of ZMAT3 in normal and tumor tissues, tumor with-LNM and without-LNM PTC tissues from TCGA dataset. (F) The differential expression of ZMAT3 in normal and tumor tissues, normal LN and metastatic LN from GSE60542 dataset. (G) qRT-PCR analysis of ZMAT3 mRNA expression in paired tumor and paracancerous tissues (n = 10). (H) ZMAT3 protein expression in normal and PTC tissues from the Protein Atlas database. (I) The correlation analysis of FN1 and ZMAT3 expression levels from cBioPortal database. (J, K) Kaplan-Meier analyses of the correlations between FN1 (I), ZMAT3 (J) expression and recurrence-free survival of PTC patients from Kmplot database.
