Table 2 Results for one-way ANCOVA for groupwise comparisons of mean \(\chi\), PCS, DCS and R2*. ANCOVA with post-hoc Welch’s t-tests were carried out with Cohen’s d reflecting the effect size. FDR-corrected q-values are shown for both group-wise tests and post-hoc tests. Bold entries indicate significance at the q < 0.05 level

From: Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies

 

Susceptibility ( \(\chi\))

Paramagnetic Component Susceptibility (PCS)

Diamagnetic Component Susceptibility (DCS)

Transverse Relaxation Rate (R2*)

ANCOVA

    

q

< 0.001

< 0.001

0.274

0.252

\(\eta ^2\)

0.151

0.122

0.025

0.032

Post-hoc t tests q-value (Cohen’s d)

    

HC v PNaSyn

0.902 (0.039)

0.392 (0.277)

0.987 (-0.016)

0.928 (-0.033)

HC v PPaSyn

0.039 (-0.582)

0.033 (-0.538)

0.987 (-0.022)

0.265 (-0.375)

HC v OaSyn

< 0.001 (-1.032)

0.002 (-0.793)

0.426 (0.321)

0.265 (-0.412)

PNaSyn v PPaSyn

0.104 (-0.515)

0.017 (-0.677)

0.987 (-0.005)

0.290 (-0.328)

PNaSyn v OaSyn

0.005 (-0.920)

0.003 (-1.056)

0.435 (0.300)

0.265 (-0.378)

PPaSyn v OaSyn

0.150 (-0.355)

0.876 (-0.036)

0.426 (0.315)

0.928 (0.021)

  1. HC: healthy controls; PNaSyn: prodromal negative alpha-synucleinopathies; PPaSyn: prodromal positive alpha-synucleinopathies; OaSyn: overt alpha-synucleinopathies; ANCOVA: analysis of covariance