Table 1 Optimization of the conditions for the ring-opening reaction of 2-(phenoxymethyl)oxirane with indole.

From: Sulfonated polystyrene foam waste as an efficient catalyst for Friedel-Crafts type reactions

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Entrya

Solvent

Time (h)

SPS loading

(mg/mmol of indole)

SGA loading

(mg/mmol of indole)

Yield for SPS (%)b

Yield for SGA (%) b

1

CH2Cl2

12

10

10

38

32

2

H2O

12

10

10

26

24

3

MeOH

12

10

10

36

34

4

EtOH

12

10

10

37

33

5

Toluene

12

10

10

42

39

6

Solvent-free

5

10

10

72

70

7

Solvent-free

5

15

15

75

72

8

Solvent-free

5

20

20

76

72

  1. aConditions: Indole (3.0 mmol), 2-(phenoxymethyl)oxirane (3.0 mmol), solvent (5.0 mL), room temperature. bIsolated yields.
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