Table 1 MR estimates of the effect of SGLT2 inhibition on intracerebral hemorrhage.
From: SGLT2 inhibition mitigates intracerebral hemorrhage risk by modulating inflammation
Method | nsnp | OR (95% CI) | P value | Q statistic | P-heterogeneity | Egger-intercept | P-pleiotropy |
|---|---|---|---|---|---|---|---|
MR egger | 14 | 0.513(0.010-25.797) | 0.744 | 6.714 | 0.876 | -0.017 | 0.545 |
Weighted median | 14 | 0.210(0.070–0.629) | 0.005 | ||||
Inverse variance weighted | 14 | 0.152(0.066–0.352) | < 0.001 | 7.101 | 0.897 | ||
Robust adjusted profile score | 14 | 0.152(0.062–0.373) | < 0.001 | ||||
Weighted mode | 14 | 0.206(0.045–0.930) | 0.061 | ||||
Bayesian analysis | 14 | 0.149(0.062–0.359) | < 0.001 | ||||
MR-PRESSO | 1.901 | 1.000 |
