Fig. 4 | Scientific Reports

Fig. 4

From: Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension

Fig. 4The alternative text for this image may have been generated using AI.

Cardiac transcriptomic and metabolomic profiling of HFpEF hearts shows strong signatures of reduced mitochondrial fuel (BCAA) and activation of ECM/fibrosis. (A) Principal component (PC) analysis and (B) heatmap of ventricular RNAseq comparing control and HFD-Renin groups (n = 5–6). (C) Volcano plot of differentially expressed genes in HFpEF (vs. control) hearts (n = 5–6). (D) KEGG pathway analysis of upregulated (yellow bars) and downregulated (blue bars) pathways. (E) Targeted metabolomics from heart tissue displaying short-chain acylcarnitine species (n = 5–7). Data displayed as mean ± SEM. Unpaired, 2-tailed Student’s t-test, with p values as displayed or * <0.05.

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