Fig. 4 | Scientific Reports

Fig. 4

From: Single-nucleotide polymorphism analysis accurately predicts multiple impairments in hippocampal activity and memory performance in a murine model of idiopathic autism

Fig. 4

Action potential kinetics of the CA3 pyramidal cells of the C58/J strain. (A) Superimposed AP spikes show the increased fast afterhyperpolarization (fAHP) phase of the action potential in the C58/J CA3 vs. C57BL/6J cells. (B) Averaged phase plots showing the membrane potential’s dynamical evolution during the action potential. Violin plots contrast the kinetic parameters of the AP obtained from the C57BL/6J and the C58/J strains. (C) The action potential amplitude and (D) the fAHP were increased in the C58/J strain compared to C57BL/6J mice. However, (E) the voltage threshold to elicit an action potential and (F) the action potential half-duration remained unchanged in both groups. (G) The maximal rise slope increased, and the (H) maximal decay slope decreased in the C58/J strain compared with the C57BL/6J strain. n = 16 cells/6 animals in C57BL/6J, n = 17 cells/5 animals in C58/J. Each symbol within the violin plots represents an individual cell’s value. *p < .05; **p < .01. Additional details of statistical analyses are in Supplementary Table S2.

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