Table 4 Factors associated with acute ischemic stroke according to exon variant.
From: Genetic and imaging features of CADASIL patients with acute ischemic stroke
Univariable analysis | Model 1* | Model 2** | Model 3*** | |||||
|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
Age | 1.007 (0.978–1.036) | 0.657 | 0.960(0.920–1.002) | 0.063- | - | - | - | - |
Male sex | 0.774 (0.398–1.508) | 0.452 | - | - | - | - | - | - |
Hypertension | 1.577 (0.690–3.605) | 0.280 | - | - | - | - | - | - |
Diabetes mellitus | 1.524 (0.545–4.260) | 0.422 | 4.147(0.993–17.314) | 0.051 | 3.311(0.887–12.358) | 0.075 | 3.360(0.900–12.550) | 0.071 |
Hyperlipidemia | 1.254 (0.605–2.599) | 0.542 | ||||||
Coronary heart disease | 0.157 (0.018–1.340) | 0.091 | 0.100(0.007–1.488) | 0.095 | ||||
Smoking history | 1.375 (0.643–2.947) | 0.412 | ||||||
Exons (others) | 1.064. (0.534–2.118) | 0.861 | Ref | |||||
Exon 3 variant | 2.330 (1.060–5.118) | 0.035 | 2.137(0.877–5.207) | 0.095 | 1.362(0.525–3.529) | 0.525 | ||
Exon 11 variant | 0.402 (0.184–0.881) | 0.023 | 0.237(0.094–0.597) | 0.002 | 0.270(0.099–0.733) | 0.010 | ||
Presence of lacune | 7.683(2.940–20.080) | < 0.001 | 5.697(1.973–16.449) | 0.001 | 8.655(3.146–23.811) | < 0.001 | 8.190(2.948–22.754) | < 0.001 |
Presence of CMB | 1.472(0.708–3.059) | 0.301 | ||||||
Deep (Fazekas grade) | ||||||||
0–1 | Ref | Ref | ||||||
2 | 4.044(1.045–15.648) | 0.043 | 2.180(0.429–11.084) | 0.348 | ||||
3 | 6.914(1.812–26.380) | 0.005 | 5.675(0.944–34.109) | 0.058 | ||||
Perivascular (Fazekas grade) | ||||||||
0–1 | Ref | |||||||
2 | 2.022(0.432–9.461) | 0.301 | ||||||
3 | 2.524(0.618–10.308) | 0.197 | ||||||
Anterior temporal pole lesions | 1.776(0.908–3.474) | 0.094 | ||||||
External capsule lesions | 1.551(0.592–4.065) | 0.372 | ||||||
